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©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 26, 2018; 6(16): 1121-1127
Published online Dec 26, 2018. doi: 10.12998/wjcc.v6.i16.1121
Published online Dec 26, 2018. doi: 10.12998/wjcc.v6.i16.1121
Safety of fecal microbiota transplantation in Chinese children: A single-center retrospective study
Xin-Yue Zhang, Yi-Zhong Wang, Xiao-Lu Li, Hui Hu, Hai-Feng Liu, Dan Li, Yong-Mei Xiao, Ting Zhang, Department of Gastroenterology, Hepatology and Nutrition, Shanghai Children’s Hospital, Shanghai Jiao Tong University, Shanghai 200040, China
Author contributions: All authors helped to perform the research; Zhang XY contributed to writing the manuscript and performing the procedures and data analysis; Wang YZ contributed to manuscript writing, study conception and design, and data analysis; Li XL contributed to writing the manuscript and collecting the data; Hu H, Liu HF, Li D and Xiao YM contributed to patient recruitment, diagnosis, and treatment; Zhang T contributed to writing the manuscript, study conception and design, cohort setting, and patient management.
Supported by Shanghai Hospital Development Center New Frontier Technology Joint Research Project , No. SHDC12017115 .
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Shanghai Children’s Hospital (2014RY015-E02).
Informed consent statement: Written informed consent was obtained from parents or legal guardians of all pediatric subjects.
Conflict-of-interest statement: All authors declare no conflicts of interest related to this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author to: Ting Zhang, PhD, Professor, Department of Gastroenterology, Hepatology and Nutrition, Shanghai Children’s Hospital, Shanghai Jiao Tong University, No. 355, Luding Road, Shanghai 200062, China. zhangt@shchildren.com.cn
Telephone: +86-21-52976338 Fax: +86-21-52976338
Received: October 15, 2018
Peer-review started: October 15, 2018
First decision: November 7, 2018
Revised: November 22, 2018
Accepted: November 30, 2018
Article in press: December 1, 2018
Published online: December 26, 2018
Processing time: 70 Days and 11.7 Hours
Peer-review started: October 15, 2018
First decision: November 7, 2018
Revised: November 22, 2018
Accepted: November 30, 2018
Article in press: December 1, 2018
Published online: December 26, 2018
Processing time: 70 Days and 11.7 Hours
Core Tip
Core tip: A retrospective study was conducted on 49 patients who underwent 114 fecal microbiota transplantation (FMT) treatments at our hospital. The safety of FMT was evaluated by short-term, long-term, and severe adverse events (AEs). The incidence of short-term AEs was 26.32% (30/114). The most common short-term AEs were abdominal pain, diarrhea, fever, and vomiting. Age and immune state had significant effects, and immune state was an independent risk factor for AEs occurrence. The risk ratio in immunodeficient patients was 3.105. Pediatricians need to be more cautious when FMT is applied to immunodeficient patients.