Case Report
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 16, 2017; 5(6): 238-246
Published online Jun 16, 2017. doi: 10.12998/wjcc.v5.i6.238
Effect of double platinum agents, combination of miriplatin-transarterial oily chemoembolization and cisplatin-hepatic arterial infusion chemotherapy, in patients with hepatocellular carcinoma: Report of two cases
Kohei Ogawa, Kenya Kamimura, Yukari Watanabe, Yosuke Motai, Daisuke Kumaki, Ryoya Seki, Akira Sakamaki, Satoshi Abe, Hirokazu Kawai, Takeshi Suda, Satoshi Yamagiwa, Shuji Terai
Kohei Ogawa, Kenya Kamimura, Yukari Watanabe, Yosuke Motai, Daisuke Kumaki, Ryoya Seki, Akira Sakamaki, Satoshi Abe, Hirokazu Kawai, Satoshi Yamagiwa, Shuji Terai, Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan
Takeshi Suda, Department of Gastroenterology and Hepatology, Uonuma Institute of Community Medicine, Niigata Medical and Dental Hospital, Minami-Uonuma, Niigata 949-7302, Japan
Author contributions: Ogawa K, Kamimura K, Watanabe Y, Motai Y, Kumaki D, Seki R, Sakamaki A and Abe S performed procedure; Kawai H, Suda T, Yamagiwa S and Terai S confirmed the therapeutic effects; Kamimura K analyzed data and prepared the manuscript.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Niigata University.
Informed consent statement: Written informed consents were obtained from the patients to present their information.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Kenya Kamimura, MD, PhD, Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachido-ri, Chuo-ku, Niigata 951-8510, Japan. kenya-k@med.niigata-u.ac.jp
Telephone: +81-25-2272207 Fax: +81-25-2270776
Received: January 15, 2017
Peer-review started: January 16, 2017
First decision: March 28, 2017
Revised: March 30, 2017
Accepted: April 18, 2017
Article in press: April 19, 2017
Published online: June 16, 2017
Core Tip

Core tip: To date, multiple treatment modalities of hepatocellular carcinoma (HCC) exist; however, only liver transplantation or surgical resection is curative. Hepatic resection remains the most frequently performed treatment modality, but curative resection cases are limited. Therefore, palliative treatment options are necessary, including transarterial chemoembolization, transarterial oily chemoembolization (TOCE), and hepatic arterial infusion chemotherapy (HAIC). We conducted a clinical trial of combination therapy with miriplatin-TOCE and cisplatin-HAIC and demonstrated its safety and efficacy for patients with unresectable HCC. Here, we presented two cases who showed good response after the several sessions of the combination therapy.