Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 16, 2015; 3(6): 525-532
Published online Jun 16, 2015. doi: 10.12998/wjcc.v3.i6.525
Published online Jun 16, 2015. doi: 10.12998/wjcc.v3.i6.525
Variant of multiple sclerosis with dementia and tumefactive demyelinating brain lesions
Sherifa A Hamed, Department of Neurology and Psychiatry, Hospital of Neurology and Psychiatry, Assiut University Hospital, Assiut 71516, Egypt
Author contributions: Hamed SA solely contributed to this work.
Ethics approval: The study was reviewed by and received exemption from the Assiut University Hospital Institutional Review Board.
Informed consent: The study participant provided written informed consent for inclusion in this case report.
Conflict-of-interest: The author declared no potential conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Sherifa A Hamed, MD, Consultant Neurologist, Professor, Department of Neurology and Psychiatry, Hospital of Neurology and Psychiatry, Assiut University Hospital, Assiut 71516, Egypt. hamed_sherifa@yahoo.com
Telephone: +2-88-2333327 Fax: +2-88-2333327
Received: September 16, 2014
Peer-review started: September 16, 2014
First decision: December 17, 2014
Revised: December 26, 2014
Accepted: March 16, 2015
Article in press: March 18, 2015
Published online: June 16, 2015
Peer-review started: September 16, 2014
First decision: December 17, 2014
Revised: December 26, 2014
Accepted: March 16, 2015
Article in press: March 18, 2015
Published online: June 16, 2015
Core Tip
Core tip: Multiple sclerosis (MS) is the most common cause of progressive neurologic handicap in young adults. MS is typically presented by sensory, motor and visual dysfunctions, abnormal visual, auditory brainstem, somatosensory and motor evoked potentials, elevated cerebrospinal fluid proteins and oligoclonal bands, and abnormal neuroimaging of the brain and spinal cord. In the literature, atypical clinical and radiological presentations or variants have been described in adults with MS which may pose diagnostic difficulties. However and in spite of the aggressive course of its tumefactive variant, good prognosis may be seen in some patients on corticosteroids.