Systematic Reviews
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 16, 2025; 13(29): 108046
Published online Oct 16, 2025. doi: 10.12998/wjcc.v13.i29.108046
High-resolution optical coherence tomography for screening ocular surface tumors: Historical markers and future directions
Ehimare Enaholo, Godwin Okoye, Mutali Musa, Ayuba Suleman, Oluwasola Ojo, Roberta Foti, Fabiana D’Esposito, Rosa Giglio, Daniele Tognetto, Caterina Gagliano, Marco Zeppieri
Ehimare Enaholo, Godwin Okoye, Department of Ophthalmology, Centre for Sight Africa Ltd, Nkpor 434101, Nigeria
Godwin Okoye, Mutali Musa, Ayuba Suleman, Department of Ophthalmology, Africa Eye Laser Center Ltd, Benin 300211, Nigeria
Mutali Musa, Department of Optometry, University of Benin, Benin 300283, Nigeria
Oluwasola Ojo, Department of Optometry, University of Ilorin, Ilorin 234031, Nigeria
Roberta Foti, Division of Rheumatology, A.O.U. Policlinico-San Marco, Catania 95123, Italy
Fabiana D’Esposito, Imperial College Ophthalmic Research Group Unit, Imperial College, London NW15QH, United Kingdom
Rosa Giglio, Daniele Tognetto, Marco Zeppieri, Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste 34129, Italy
Caterina Gagliano, Department of Medicine and Surgery, University of Enna "Kore", Enna 94100, Italy
Caterina Gagliano, Mediterranean Foundation, G.B. Morgagni, Catania 95100, Italy
Marco Zeppieri, Department of Ophthalmology, University Hospital of Udine, Udine 33100, Italy
Co-corresponding authors: Caterina Gagliano and Marco Zeppieri.
Author contributions: Enaholo E and Musa M wrote the outline of the manuscript; Enaholo E, Zeppieri M, and Musa M did the research and writing of the manuscript; Zeppieri M and Ayuba S assisted in the writing of the draft and final manuscript; Enaholo E and Okoye G were responsible for the conception and design of the study; Enaholo E, Okoye G, Suleman A, Ojo O, Foti R, D’Esposito F, Giglio R, Tognetto D, Gagliano C, Musa M, and Zeppieri M assisted in the research, writing, and editing of the manuscript; Okoye G contributed to the scientific editing of the manuscript; Musa M, Enaholo E, and Zeppieri M assisted in the editing and critical revisions of the manuscript, and viewed all versions of the manuscript; Gagliano C and Zeppieri M played important and indispensable roles in the data interpretation and manuscript preparation as the co-corresponding authors; All authors provided final approval of the manuscript.
Conflict-of-interest statement: All authors have no conflicts of interest to declare.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Marco Zeppieri, MD, PhD, Department of Ophthalmology, University Hospital of Udine, p. le S. Maria della Misericordia 15, Udine 33100, Italy. mark.zeppieri@asufc.sanita.fvg.it
Received: April 9, 2025
Revised: May 5, 2025
Accepted: July 15, 2025
Published online: October 16, 2025
Processing time: 147 Days and 0.7 Hours
Core Tip

Core Tip: The emergence of optical coherence tomography (OCT) has given healthcare systems a deeper understanding into tissue systems as related to both the abnormal and normal patient. In the eye, anterior segment OCT is gradually becoming the gold standard for diagnosis and documentation of pathologies in the front of the eye. An understanding of its development, application and uptake is important to the modern-day eye clinician.