Shi DD, Tian J, Ding J. Adenosine deaminase in pleural effusion: Bridging diagnosis and the pathophysiology of inflammation. World J Clin Cases 2025; 13(22): 106925 [DOI: 10.12998/wjcc.v13.i22.106925]
Corresponding Author of This Article
Ju Tian, Department of Burns and Plastic Surgery, Zhongshan People’s Hospital, Sunwen East Road, Zhongshan 528400, Guangdong Province, China. tian-ju@163.com
Research Domain of This Article
Medical Laboratory Technology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Adenosine deaminase in pleural effusion: Bridging diagnosis and the pathophysiology of inflammation
Dan-Dan Shi, Ju Tian, Jing Ding
Dan-Dan Shi, Jing Ding, Department of Plastic Surgery, Zhongshan People’s Hospital, Zhongshan 528400, Guangdong Province, China
Ju Tian, Department of Burns and Plastic Surgery, Zhongshan People’s Hospital, Zhongshan 528400, Guangdong Province, China
Co-corresponding authors: Ju Tian and Jing Ding.
Author contributions: Tian J and Ding J conceived and designed the overall concept and structure of the manuscript; Shi DD and Ding J contributed to writing and editing the manuscript, preparing illustrations, and reviewing the relevant literature. Both Tian J and Ding J have played important and indispensable roles in the manuscript preparation as the co-corresponding authors.
Conflict-of-interest statement: All authors declare that they have no competing interests.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ju Tian, Department of Burns and Plastic Surgery, Zhongshan People’s Hospital, Sunwen East Road, Zhongshan 528400, Guangdong Province, China. tian-ju@163.com
Received: March 11, 2025 Revised: April 3, 2025 Accepted: April 16, 2025 Published online: August 6, 2025 Processing time: 64 Days and 15.5 Hours
Core Tip
Core Tip: Maranhão et al introduce a standardized pleural adenosine deaminase (P-ADA) cutoff (≥ 9.00 U/L) for diagnosing inflammatory pleural effusions, validated via rigorous statistical analysis in a Brazilian cohort. This addresses inconsistencies in international reference values and links P-ADA to purinergic signaling and ADA2 isoform activation in macrophages and lymphocytes. The study emphasizes P-ADA’s clinical utility as a non-invasive, cost-effective biomarker to reduce the need for invasive procedures (e.g., thoracentesis) and improve diagnostic accuracy in resource-limited settings. Its integration into clinical workflows could streamline management, reduce healthcare costs, and enable early treatment stratification, pending multicenter validation for broader global application.
