Observational Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 16, 2023; 11(29): 7075-7081
Published online Oct 16, 2023. doi: 10.12998/wjcc.v11.i29.7075
Effect of T-regulatory cells and interleukin-35, interleukin-10, and transforming growth factor-beta on diffuse large B-cell lymphoma
Hao Wu, Hui-Cong Sun, Gui-Fang Ouyang
Hao Wu, Gui-Fang Ouyang, Department of Hematology, The First Affiliated Hospital of Ningbo University, Ningbo 315010, Zhejiang Province, China
Hui-Cong Sun, Adult Internal Medicine, Ningbo Women and Children's Hospital, Ningbo 315012, Zhejiang Province, China
Author contributions: Wu H designed and performed the research and wrote the article, Sun HC edited the article, Ouyang GF supervised the article.
Supported by Zhejiang TCM Science and Technology Project, No. 2023ZL653; Zhejiang Medical Science and Technology Plan Project-Clinical Research Application Project A, No. 2021KY273
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of The First Affiliated Hospital of Ningbo University.
Informed consent statement: All study participants or their legal guardians provided written informed consent before study enrollment.
Conflict-of-interest statement: All the authors declare no conflict of interest.
Data sharing statement: All authors agree to data sharing.
STROBE statement: The authors have read the STROBE Statement – checklist of items, and the manuscript was prepared and revised according to the STROBE Statement – checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gui-Fang Ouyang, MD, Chief Physician, Department of Hematology, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Ningbo 315010, Zhejiang Province, China. oyguifangoy@163.com
Received: August 4, 2023
Peer-review started: August 4, 2023
First decision: August 24, 2023
Revised: September 8, 2023
Accepted: September 18, 2023
Article in press: September 18, 2023
Published online: October 16, 2023
Core Tip

Core Tip: To study the expression and significance of T-regulatory cells (Tregs) interleukin (IL)-35, IL-10, and transforming growth factor-beta (TGF-β) in diffuse large B-cell lymphoma (DLBCL). Seventy-nine patients were enrolled and divided into three groups according to the evaluation of clinical efficacy: Incipient, effectively treated, and relapsed-refractory. Thirty healthy individuals comprised the control group. The expression of Tregs and their associated factors IL-35, IL-10, and TGF-β in the four groups were analyzed. Finally, we found that Tregs, IL-35, and IL-10 are closely associated with the occurrence and development of DLBCL, which may be helpful in the analysis of disease prognosis.