Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 16, 2023; 11(26): 6206-6212
Published online Sep 16, 2023. doi: 10.12998/wjcc.v11.i26.6206
Severe inflammatory disorder in trisomy 8 without myelodysplastic syndrome and response to methylprednisolone: A case report
Fei-Yan Pan, Hao-Zhe Fan, Shun-Hong Zhuang, Li-Fei Pan, Xiang-Hong Ye, Hong-Jie Tong
Fei-Yan Pan, Hao-Zhe Fan, Li-Fei Pan, Hong-Jie Tong, Intensive Care Medicine, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua 321000, Zhejiang Province, China
Shun-Hong Zhuang, Department of Clinical Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua 321000, Zhejiang Province, China
Xiang-Hong Ye, Administration Division, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua 321000, Zhejiang Province, China
Author contributions: Pan FY and Fan HZ were the patient’s intensive care physicians, they also collected the material and contributed to manuscript drafting; Tong HJ was the intensive care physicians, he reviewed the literature and contributed to manuscript drafting; Zhuang SH contributed to the bone marrow puncture report interpreting; Pan LF and Ye XH were the patient’s nurse, they also contributed to data collection; All authors have read and approved the final version of the manuscript.
Supported by Major Project of Jinhua Science and Technology Bureaun, No. 2021-3-025.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong-Jie Tong, MD, Attending Doctor, Intensive Care Medicine, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, No. 365 East Renmin Road, Jinhua 321000, Zhejiang Province, China. 444370182@qq.com
Received: May 6, 2023
Peer-review started: May 6, 2023
First decision: August 4, 2023
Revised: August 17, 2023
Accepted: August 23, 2023
Article in press: August 23, 2023
Published online: September 16, 2023
Core Tip

Core Tip: Trisomy 8 patients without myelodysplastic syndrome consistently present with auto-inflammatory syndrome, the gastrointestinal tract being the most commonly affected site. Because initial presentations with severe pneumonia are less common in trisomy 8 patients, there is limited experience on treating this. We treated a 27-year-old patient with trisomy 8 who was diagnosed with severe pneumonia and responded to methylprednisolone. The patient was eventually discharged in good clinical condition. This case shows that, in trisomy 8 patients, severe inflammatory disorders with pulmonary involvement can occur before progression to hematological malignancies. Steroids may play an important role in treating these patients.