Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 26, 2022; 10(36): 13408-13417
Published online Dec 26, 2022. doi: 10.12998/wjcc.v10.i36.13408
Hepatic sinusoidal obstruction syndrome induced by tacrolimus following liver transplantation: Three case reports
Jia-Yun Jiang, Yu Fu, Yan-Jiao Ou, Lei-Da Zhang
Jia-Yun Jiang, Yan-Jiao Ou, Lei-Da Zhang, Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China
Yu Fu, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China
Author contributions: Jiang JY designed the study and wrote the manuscript; Jiang JY and Fu Y collected and analyzed the clinical data; Ou YJ and Zhang LD guided the diagnosis and treatment of HSOS; and all authors contributed to the revision of the manuscript and approved the submitted version.
Supported by Surface Project of National Natural Science Foundation of China, No. 81972760; The Joint Project of Chongqing Health Commission and Science and Technology Bureau, No. 2022QNXM020; Doctoral Through Train Scientific Research Project of Chongqing, No. CSTB2022BSXM-JCX0004.
Informed consent statement: The study performed followed the principles of the Declaration of Helsinki. The requirement for ethical approval was approved by the Ethics Committee of Southwest Hospital, Third Military Medical University (Army Medical University). Written informed consents were obtained from the three patients or their guardians for the publication of this report and the clinical data. A copy of the consent form is available for review by the Editor of this journal.
Conflict-of-interest statement: The authors declare that they have no competing interests.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lei-Da Zhang, MD, Professor, Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), No. 29 Gaotanyan Street, Shapingba District, Chongqing 400038, China. 2518569931@qq.com
Received: September 8, 2022
Peer-review started: September 8, 2022
First decision: September 27, 2022
Revised: October 7, 2022
Accepted: October 23, 2022
Article in press: October 23, 2022
Published online: December 26, 2022
Core Tip

Core Tip: Tacrolimus-induced hepatic sinusoidal obstruction syndrome (HSOS) is a scarce but severe complication after liver transplantation. It lacks specific symptoms and diagnostic criteria. Timely diagnosis of HSOS is based on clinical symptoms, radiological and histological examinations. Discontinuation of tacrolimus is the only effective treatment. Transplantation physicians should be aware of this rare complication potentially induced by tacrolimus.