Clinical and Translational Research
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 26, 2022; 10(33): 12089-12103
Published online Nov 26, 2022. doi: 10.12998/wjcc.v10.i33.12089
Comprehensive analysis of the relationship between cuproptosis-related genes and esophageal cancer prognosis
Hao Xu, Qian-Cheng Du, Xin-Yu Wang, Ling Zhou, Jian Wang, Ying-Ying Ma, Meng-Yao Liu, Hua Yu
Hao Xu, General Surgery, Shanghai Xuhui Central Hospital, Shanghai 200031, China
Qian-Cheng Du, Jian Wang, Ying-Ying Ma, Meng-Yao Liu, Thoracic Surgery, Shanghai Xuhui Central Hospital, Shanghai 200031, China
Xin-Yu Wang, Ling Zhou, Hua Yu, General Surgery, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai 200434, China
Author contributions: Xu H and Du QC analyzed the data and wrote the manuscript; Yu H designed the study; Zhou L, Wang J, Ma YY, and Liu MY collected the data and corrected the paper; all authors have read and approved the final manuscript.
Supported by the Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine Talent Boosting Plan, No. SY-XKZT-2020-3007.
Institutional review board statement: The data for the study came from public databases and did not involve blood or tissue samples from humans or animals. Therefore, there were no ethical issues involved in this study.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Hua Yu, MM, Associate Chief Physician, General Surgery, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, No. 1279 Sanmen Road, Shanghai 200434, China.
Received: June 18, 2022
Peer-review started: June 18, 2022
First decision: August 6, 2022
Revised: August 18, 2022
Accepted: October 9, 2022
Article in press: October 9, 2022
Published online: November 26, 2022
Core Tip

Core Tip: Esophageal carcinoma has a poor prognosis and is one of the major causes of cancer-related deaths worldwide. Despite recent advancements in the surgical and pharmacological treatment of esophageal cancer, the prognosis remains poor. Copper toxicity has been linked to the incidence and progression of esophageal cancer in numerous studies. At the gene level, however, the probable biochemical mechanism is unknown. We included 19 cuproptosis-related genes and screened a gene that could successfully predict the prognosis of esophageal cancer by statistical analysis to further elucidate the role of cuproptosis-related genes in impacting the prognosis of esophageal cancer.