Copyright
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 14, 2022; 10(2): 733-740
Published online Jan 14, 2022. doi: 10.12998/wjcc.v10.i2.733
Published online Jan 14, 2022. doi: 10.12998/wjcc.v10.i2.733
Accelerated Infliximab Induction for Severe Lower Gastrointestinal Bleeding in a Young Patient with Crohn’s Disease: A Case Report
Jing Zeng, Feng Shen, Jian-Gao Fan, Wen-Song Ge, Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
Author contributions: Zeng J, Shen F, and Ge WS were the patient’s attending physician, reviewed the literature and contributed to manuscript drafting; Fan JG and Ge WS were responsible for the revision of the manuscript for important intellectual content; all authors issued final approval for the version to be submitted.
Supported by National Natural Science Foundation of China , No. 81873565 and No. 82100605 ; SJTU Trans-med Awards Research , No. 20190104 ; Star Program of Shanghai Jiaotong University , No. YG2021QN54 .
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wen-Song Ge, PhD, Chief Doctor, Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 1665 Kongjiang Road, Shanghai 200092, China. gewensong@xinhuamed.com.cn
Received: August 19, 2021
Peer-review started: August 19, 2021
First decision: October 16, 2021
Revised: October 23, 2021
Accepted: December 7, 2021
Article in press: December 7, 2021
Published online: January 14, 2022
Peer-review started: August 19, 2021
First decision: October 16, 2021
Revised: October 23, 2021
Accepted: December 7, 2021
Article in press: December 7, 2021
Published online: January 14, 2022
Core Tip
Core Tip: Severe lower gastrointestinal bleeding (SLGIB) is a rare complication of Crohn's disease (CD) that is potentially life-threatening. The treatment of these patients is a clinical challenge. Monoclonal anti-TNFα antibody infliximab (IFX) can induce relatively fast mucosal healing. It has been reported for the treatment of SLGIB, but there are few reports on accelerated IFX induction in CD patients with SLGIB. We present a patient with CD complicated with SLGIB. The bleeding was finally controlled, and colonoscopy showed mucosal healing after accelerated IFX induction.