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World J Clin Cases. Jun 16, 2013; 1(3): 96-105
Published online Jun 16, 2013. doi: 10.12998/wjcc.v1.i3.96
Monitoring photodynamic therapy of head and neck malignancies with optical spectroscopies
Ulas Sunar
Ulas Sunar, Department of Cell Stress Biology and Oncology, PDT Center, Roswell Park Cancer Institute, Buffalo, New York, NY 14263, United States
Author contributions: Sunar U solely contributed to this paper.
Supported by RPCI Startup Grant (P30CA16056) and NCI CA55791
Correspondence to: Ulas Sunar, PhD, Department of Cell Stress Biology and Oncology, PDT Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, United States.
Telephone: +1-716-8453311 Fax: +1-716-8458920
Received: March 6, 2013
Revised: April 2, 2013
Accepted: May 7, 2013
Published online: June 16, 2013
Processing time: 99 Days and 20.8 Hours
Core Tip

Core tip: Most treatment approaches including chemo-radiation and surgery can induce prolonged morbidity and functional loss resulting in severe impairment of patients’ quality of life. Photodynamic therapy (PDT) is an emerging alternative treatment option without any significant accumulative side effects due to targeted light illumination and preferential accumulation of photosensitizers (PSs). However, PDT has not found widespread applications at the clinic mainly due to variable responses that originated from unstandardized treatment protocols such as different light and PS doses. Novel optical imaging techniques can quantify PDT-dosimetry related parameters such as local light and PS dose in tissue and PDT response related parameters such as tissue oxygenation and blood flow noninvasively without any contrast agent administration, thereby providing real-time feedback about the treatment efficacy for optimizing and standardizing PDT.