Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 26, 2021; 9(21): 5830-5839
Published online Jul 26, 2021. doi: 10.12998/wjcc.v9.i21.5830
Macular ganglion cell complex injury in different stages of anterior ischemic optic neuropathy
Wei Zhang, Xin-Quan Sun, Xiao-Yan Peng
Wei Zhang, Xiao-Yan Peng, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China
Wei Zhang, Beijing Aier Intech Eye Hospital, Beijing 100021, China
Xin-Quan Sun, China-Japanese Friendship Hospital, Beijing 100029, China
Author contributions: Sun XQ contributed to the conception of the study; Peng XY designed the work; Zhang W contributed to the acquisition of the data; all authors contributed to the analysis and interpretation of data; Zhang W drafted the initial manuscript; Sun XQ and Peng XY revised the manuscript critically for important intellectual content; All authors have read the manuscript and gave their final approval of the version to be published.
Institutional review board statement: This study was reviewed and approved by the Institutional Ethical Review Boards of Beijing Aier Intech Eye Hospital, Beijing, China.
Informed consent statement: Informed consent statement was waived.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Xiao-Yan Peng, PhD, Doctor, Professor, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No. 17 Hougou Lane, Chongnei Street, Beijing 100005, China.
Received: January 1, 2021
Peer-review started: January 1, 2021
First decision: January 24, 2021
Revised: March 4, 2021
Accepted: June 17, 2021
Article in press: June 17, 2021
Published online: July 26, 2021
Processing time: 200 Days and 9.2 Hours
Research background

Presently the changes of macular ganglion cell complex (mGCC) thickness were assessed for neuro-ophthalmology and mGCC atrophic injury caused by chiasma opticum, visual radiation, and visual cortical diseases. This study aimed to explore the mGCC injury at different stages in anterior ischemic optic neuropathy (AION) and the clinical significance.

Research motivation

The pathogenesis, clinical manifestations, and clinical treatments of AION are yet elusive. The spectral domain optical coherence tomography examination is objective and non-injurious and can be widely used in the clinical examination of the AION.

Research objectives

Through study, the mGCC injury was different at the stages in AION. The most severe ganglion cell layer + inner plexus layer thinning occurred early when potential neuroprotective or protective therapy must be provided before 3 wk to reduce retinal ganglion cells loss.

Research methods

Ganglion cell layer plus inner plexiform layer is acutely unaffected in the early inflammatory edema stage of the AION and provides a reliable method to measure the structure of retinal neurons using optical coherence tomography 3D segmentation.

Research results

The “subnormal eye” was put forward as a clinical phenomenon often observed by the authors during mGCC examination. The onset time of AION was defined as early stage (within 3 wk of onset), middle stage (course of disease of 3 wk to 2 mo), and late stage (course of disease > 2 mo).

Research conclusions

The ganglion cell layer + inner plexus layer segmentation measurement of the spectral domain optical coherence tomography was superior to RNFL thickness as a biomarker for early structural loss in nerve ophthalmology.

Research perspectives

The mGCC analysis can be widely used in the study of nerve ophthalmology.