Published online Feb 16, 2023. doi: 10.12998/wjcc.v11.i5.1019
Peer-review started: November 7, 2022
First decision: December 20, 2022
Revised: December 26, 2022
Accepted: January 10, 2023
Article in press: January 10, 2023
Published online: February 16, 2023
Lacunes and glucose variability (GV) are gaining growing attention.
The association between GV, the severity of lacunes and the cognitive impairment in lacune patients with type 2 diabetes mellitus (T2DM) is still unknown.
To explore the correlation between GV, lacune burden and cognitive function in patients with lacunes complicated with T2DM.
Seventy-two h continuous blood glucose monitoring was performed. The Montreal cognitive assessment was used to assess cognitive function. The burden of lacunes was evaluated using magnetic resonance imaging findings. Multifactorial logistic regression analysis was used to study the affecting the lacune load and cognitive impairment in patients. To predict the value of patients' cognitive impairment with lacunes complicated with T2DM, a receiver operating characteristic curve and a nomogram prediction model were constructed.
Standard deviation and percentage coefficient of variation (%CV) were the risk factors for an increased infarct burden in lacune patients complicated with T2DM. Time of range (TIR) is a protective factor. In addition, an increased SD, %CV were the risk factors for cognitive impairment in patients with lacunes complicated with T2DM. TIR is a protective factor.
Blood glucose variability is closely associated with the level of lacune burden and cognitive dysfunction in lacune patients combined with T2DM. %CV, TIR have a certain predictive effect in cognitive impairment in lacune patients.
Prospective studies are further needed to verify the results of this paper.