Qiu C, Feng D. Efficacy and anti-inflammatory analysis of glucocorticoid, antihistamine and leukotriene receptor antagonist in the treatment of allergic rhinitis. World J Clin Cases 2023; 11(28): 6725-6732 [PMID: 37901022 DOI: 10.12998/wjcc.v11.i28.6725]
Corresponding Author of This Article
Chen Qiu, MD, Doctor, Department of Pharmacy, Hongshan District Health Service Center, No. 70 Nanhu Road, Hongshan District, Wuhan 430000, Hubei Province, China. qc07200@163.com
Research Domain of This Article
Otorhinolaryngology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Oct 6, 2023; 11(28): 6725-6732 Published online Oct 6, 2023. doi: 10.12998/wjcc.v11.i28.6725
Efficacy and anti-inflammatory analysis of glucocorticoid, antihistamine and leukotriene receptor antagonist in the treatment of allergic rhinitis
Chen Qiu, Dai Feng
Chen Qiu, Department of Pharmacy, Hongshan District Health Service Center, Wuhan 430000, Hubei Province, China
Dai Feng, Department of Ear-Nose-Throat, Wuchang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan 430063, Hubei Province, China
Author contributions: Qiu C and Feng D contributed equally to this work; Feng D conceived and designed the experiments; Qiu C and Feng D selected the literature, extracted data and analyzed it; Feng D and Qiu C wrote the manuscript.
Institutional review board statement: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent statement: This study is a retrospective study, therefore informed consent forms are exempted.
Conflict-of-interest statement: The authors declare no competing financial interest.
Data sharing statement: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chen Qiu, MD, Doctor, Department of Pharmacy, Hongshan District Health Service Center, No. 70 Nanhu Road, Hongshan District, Wuhan 430000, Hubei Province, China. qc07200@163.com
Received: August 1, 2023 Peer-review started: August 1, 2023 First decision: August 16, 2023 Revised: August 29, 2023 Accepted: September 5, 2023 Article in press: September 5, 2023 Published online: October 6, 2023
ARTICLE HIGHLIGHTS
Research background
Glucocorticoids, antihistamines and leukotriene receptor antagonists are excellent therapeutic agents for allergic rhinitis (AR) at present, but the existing research lacks the comprehensive clinical effect comparison and analysis of the three.
Research motivation
To explore the clinical and anti-inflammatory effects of glucocorticoid, antihistamine and leukotriene receptor antagonist on AR.
Research objectives
To systematically evaluate the therapeutic effect of glucocorticoid, antihistamine and leukotriene receptor antagonist on AR, and evaluate its anti-inflammatory level to guide the follow-up clinical treatment.
Research methods
To evaluate the clinical efficacy, anti-inflammatory reaction and adverse reactions before and after treatment and between groups, and to comprehensively evaluate the efficacy of leukotriene receptor antagonists, glucocorticoids and antihistamines.
Research results
All three drugs have certain therapeutic effects, and the therapeutic effect of glucocorticoid combined with antihistamine is better than that of leukotriene receptor antagonist. Glucocorticoid combined with antihistamine has better anti-inflammatory effect and lower adverse reactions.
Research conclusions
Glucocorticoids and antihistamines are more effective in the treatment of AR, and it is better to reduce the level of serum inflammatory indicators and have lower adverse reactions.
Research perspectives
Summarize the common drugs used in the treatment of AR, and comprehensively analyze the clinical efficacy, anti-inflammatory level and adverse reactions of these drugs to serve clinical treatment.
