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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Intestinal complications in patients with Crohn’s disease in the Brazilian public healthcare system between 2011 and 2020
Ligia Yukie Sassaki, Adalberta Lima Martins, Rodrigo Galhardi-Gasparini, Rogerio Saad-Hossne, Alessandra Mileni Versut Ritter, Tania Biatti Barreto, Taciana Marcolino, Bruno Balula, Claudia Yang-Santos
Ligia Yukie Sassaki, Department of Internal Medicine, São Paulo State University - UNESP, Medical School, 18618687, Botucatu, Brazil
Adalberta Lima Martins, Department of Gastroenterology, State Office for Pharmaceutical Assistance at Espírito Santo Health Office, Vitoria 29017-010, Espirito Santo, Brazil
Rodrigo Galhardi-Gasparini, Department of Gastroenterology, SETE – Specialized Medical Center, Marilia 17502-020, Sao Paulo, Brazil
Rogerio Saad-Hossne, Department of Surgery, São Paulo State University - UNESP, Medical School, 18618687, Botucatu, Brazil
Alessandra Mileni Versut Ritter, Bruno Balula, Real World Evidence, IQVIA Brazil, 04719-002, Sao Paulo, Brazil
Tania Biatti Barreto, Taciana Marcolino, Medical Affairs, Takeda Pharmaceuticals Brazil, 04794-000, Sao Paulo, Brazil
Claudia Yang-Santos, Clinical Research, Takeda Pharmaceuticals Brazil, 04794-000, Sao Paulo, Brazil
Author contributions: Sassaki LY, Galhardi-Gasparini R, Martins AL, Saad-Hossne R, Barreto TB, Marcolino T and Yang Santos C participated in designed, interpretation of the data and revised the article critically for important intellectual content; Ritter AMV and Balula B participated in the acquisition, analysis and draft the initial manuscript.
Supported by Takeda Pharmaceutical Brazil.
Conflict-of-interest statement: Dr. Yang-Santos reports grants from Takeda Pharmaceuticals Brazil, during the conduct of the study; Sassaki LY is a speaker for Janssen and Takeda and participates in the advisory boards of Takeda and AbbVie; Martins AL served on the advisory boards of Takeda, AbbVie, Janssen, Pfizer, and Amgen and is a speaker for Amgen and Janssen; Galhardi-Gasparini R is a speaker for Janssen, Takeda, and AbbVie; Saad-Hossne R is a speaker for Novartis and is on the advisory boards for AbbVie, Takeda, Janssen, Pfizer, Fresenius, and Amgen; Ritter AMV and Balula B are employees of IQVIA, Brazil; Marcolino T, Barreto TB, and Yang-Santos C are employees of Takeda Pharmaceuticals, Brazil.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE statement, and the manuscript was prepared and revised according to the STROBE statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Claudia Yang-Santos, BPharm, MSc, PhD, Research Scientist, Clinical Research, Takeda Pharmaceuticals Brazil, Av. das Nações Unidas, 14.401 - Torre Jequitibá - 10º, 11º e 12º andares, 04794-000, Sao Paulo, Brazil. clausantos2910@gmail.com
Received: January 9, 2023
Peer-review started: January 9, 2023
First decision: February 15, 2023
Revised: February 27, 2023
Accepted: April 6, 2023
Article in press: April 6, 2023
Published online: May 16, 2023
ARTICLE HIGHLIGHTS
Research background
Patients with Crohn's disease (CD) undergoing therapy available in the public healthcare system (Sistema Único de Saúde) in Brazil over the last decade.
Research motivation
Observe patients with CD who initiated and either only received conventional therapy (CVT) or also initiated anti-tumor necrosis factor (anti-TNF).
Research objectives
Verify the real-world intestinal complications (ICs) of patients with CD in the Brazilian public healthcare system.
Research methods
Patients with CD with at least one claim of CVT (sulfasalazine, azathioprine, mesalazine, or methotrexate). IC was defined as a CD-related hospitalization, pre-defined procedure codes (from rectum or intestinal surgery groups), and/or associated disease (pre-defined international classification of diseases – 10th revision codes), and overall (one or more type of ICs).
Research results
This study highlights a consistent rate of ICs over time in all the CD populations assessed, especially in patients exposed to anti-TNF therapy.
Research conclusions
The Brazilian public health care system should continue to develop additional strategies for treading CD.
Research perspectives
Effective CD treatment in Brazil’s public healthcare system may require additional strategies.
