Gao Y, Ge JT. Prognostic role of pretreatment serum ferritin concentration in lung cancer patients: A meta-analysis. World J Clin Cases 2022; 10(33): 12230-12239 [PMID: 36483825 DOI: 10.12998/wjcc.v10.i33.12230]
Corresponding Author of This Article
Jin-Tong Ge, MD, Professor, Department of Cardiology Surgery, The Affiliated Huaian No. 1 People’s Hospital of Nanjing Medical University, No. 1 Yellow River West Road, Huaian 223001, Jiangsu Province, China. 15851861990@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Nov 26, 2022; 10(33): 12230-12239 Published online Nov 26, 2022. doi: 10.12998/wjcc.v10.i33.12230
Prognostic role of pretreatment serum ferritin concentration in lung cancer patients: A meta-analysis
Yang Gao, Jin-Tong Ge
Yang Gao, Jin-Tong Ge, Department of Cardiology Surgery, The Affiliated Huaian No. 1 People’s Hospital of Nanjing Medical University, Huaian 223001, Jiangsu Province, China
Author contributions: Ge JT made the substantial contributions to the conception and design of the work; Gao Y and Ge JT searched, selected materials and extracted data; Gao Y wrote this manuscript; Gao Y and Ge JT revised the paper carefully and also contributed to the statistical analysis; All authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors declare that there are no competing interests associated with this manuscript.
PRISMA 2009 Checklist statement: This meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA 2009) checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jin-Tong Ge, MD, Professor, Department of Cardiology Surgery, The Affiliated Huaian No. 1 People’s Hospital of Nanjing Medical University, No. 1 Yellow River West Road, Huaian 223001, Jiangsu Province, China. 15851861990@163.com
Received: August 23, 2022 Peer-review started: August 23, 2022 First decision: October 17, 2022 Revised: October 19, 2022 Accepted: October 24, 2022 Article in press: October 24, 2022 Published online: November 26, 2022
ARTICLE HIGHLIGHTS
Research background
The association between pretreatment serum ferritin concentration (SFC) and long-term survival in lung cancer remains unclear now.
Research motivation
Whether the pretreatment SFC could play a role in predicting long-term survival in lung cancer remains unclear.
Research objectives
To identify the prognostic value of pretreatment SFC in lung cancer patients based on current evidence.
Research methods
The PubMed, EMBASE and Web of Science databases were searched from inception to May 29, 2022 for relevant studies. The primary endpoint was overall survival (OS) and the hazard ratios (HRs) with 95% confidence intervals (CIs) were combined to assess the predictive role of pretreatment SFC for long-term survival of lung cancer patients. All statistical analysis was conducted by STATA 15.0.
Research results
A total of 12 retrospective studies involving 1654 patients were included. The pooled results manifested that increased pretreatment SFC was significantly associated with worse OS (HR = 1.09, 95%CI: 1.03-1.15, P = 0.004). Subgroup analysis based on the country (China vs non-China) showed similar results. However, subgroup analysis stratified by tumor type revealed inconsistent results (lung cancer: HR = 1.39, P = 0.008; small cell lung cancer: HR = 1.99, P = 0.175; non-small cell lung cancer: HR = 1.03, P = 0.281).
Research conclusions
Pretreatment SFC might serve as a promising prognostic indicator in lung cancer patients and elevated pretreatment SFC predicts worse prognosis.
Research perspectives
The pretreatment SFC might contribute to the clinical management and treatment of lung cancer patients.
