Retrospective Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 6, 2022; 10(31): 11371-11380
Published online Nov 6, 2022. doi: 10.12998/wjcc.v10.i31.11371
Dynamic changes of estimated glomerular filtration rate are conversely related to triglyceride in non-overweight patients
Si-Qi Liu, Xiu-Jun Zhang, Yuan Xue, Rui Huang, Jian Wang, Chao Wu, Yi-Shan He, Ya-Ru Pan, Long-Gen Liu
Si-Qi Liu, Yi-Shan He, Ya-Ru Pan, Changzhou Clinical Medical College, Nanjing Medical University, Changzhou 213000, Jiangsu Province, China
Xiu-Jun Zhang, Yuan Xue, Long-Gen Liu, Institute of Hepatology, The Third People’s Hospital of Changzhou, Changzhou 213000, Jiangsu Province, China
Rui Huang, Jian Wang, Chao Wu, Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing 210008, Jiangsu Province, China
Author contributions: Liu LG, Wu C, and Xue Y desiged the study; Liu SQ, Xue Y, Huang R, Wang J, Pan YR, and He YS contributed data collection; Liu SQ, Xue Y, Pan YR, and He YS performed the data analysis; Liu SQ, Zhang XJ, and Xue Y drafted the manuscript; All authors read and approved the final manuscript.
Supported by the 333 High-Level Talents Project of Jiangsu Province, No. LGY2020032; the Science and Technology Project of Changzhou, No. CJ20200057; Qingmiao Talents Cultivation Project of Changzhou Health Commission, No. CZQM2020089.
Institutional review board statement: The study was approved by the Ethics Committee of the Third People’s Hospital of Changzhou according to the Declaration of Helsinki 1975.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors declare no conflicts of interest for this article.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at czsykjk@163.com. Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Long-Gen Liu, MD, Chief Doctor, Dean, Doctor, Professor, Institute of Hepatology, The Third People’s Hospital of Changzhou, No. 300 Lanling North Road, Changzhou 213000, Jiangsu Province, China. ssewllg@163.com
Received: August 1, 2022
Peer-review started: August 1, 2022
First decision: August 22, 2022
Revised: August 30, 2022
Accepted: September 23, 2022
Article in press: September 23, 2022
Published online: November 6, 2022
ARTICLE HIGHLIGHTS
Research background

Tenofovir disoproxil fumarate (TDF) is recommended as one of the first-line antiviral agents. The effects of TDF on lipid profiles in patients with chronic hepatitis B (CHB) and overweight are largely unknown.

Research motivation

Overweight is a global pandemic associated with dyslipidemia. Correlation between triglyceride (TG) and estimated glomerular filtration rate (eGFR) remains largely unclear.

Research objectives

To determine the impact of 3-year TDF treatment on lipid metabolism profiles and renal function in Chinese patients with CHB and overweight.

Research methods

This multi-centre, retrospective cohort study included CHB patients who received TDF treatment. According to the body mass index (BMI) at the initiation of TDF treatment, CHB patients were divided into different groups. Changes of lipid profiles and renal function, as well as the risk factors for eGFR < 90 mL/(min·1.73 m2) were analyzed. Spearman correlation was used to analyze the correlation between eGFR and lipid profiles.

Research results

In non-overweight patients, TG was negatively correlated with GFR at the four-time points (P = 0.002, 0.030, 0.007, 0.008, respectively).

Research conclusions

There is a negative relation between TG and changes in eGFR during TDF treatment in patients with CHB and normal BMI.

Research perspectives

TG regulation may be beneficial for reducing the renal toxicity of TDF.