Zhang LY, Chen Y, Ao YZ. Value of thyroglobulin combined with ultrasound-guided fine-needle aspiration cytology for diagnosis of lymph node metastasis of thyroid carcinoma. World J Clin Cases 2022; 10(2): 492-501 [PMID: 35097074 DOI: 10.12998/wjcc.v10.i2.492]
Corresponding Author of This Article
Yong Chen, BM BCh, Chief Physician, Department of Thyroid Surgery, Affiliated Hospital of Chengde Medical University, No. 36 Nanyingzi Street, Shuangqiao District, Chengde 067000, Hebei Province, China. chenyong2021@yeah.net
Research Domain of This Article
Surgery
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jan 14, 2022; 10(2): 492-501 Published online Jan 14, 2022. doi: 10.12998/wjcc.v10.i2.492
Value of thyroglobulin combined with ultrasound-guided fine-needle aspiration cytology for diagnosis of lymph node metastasis of thyroid carcinoma
Liu-Yang Zhang, Yong Chen, Ya-Zhou Ao
Liu-Yang Zhang, Yong Chen, Ya-Zhou Ao, Department of Thyroid Surgery, Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei Province, China
Author contributions: Zhang LY and Chen Y designed the research study; Zhang LY and Ao YZ performed the research, analyzed the data and wrote the manuscript; all authors have read and approve the final manuscript.
Supported byThe Research and Development Project of Science and Technology of Chengde City, No. 201706A046.
Institutional review board statement: The study was reviewed and approved by the Affiliated Hospital of Chengde Medical College Institutional Review Board.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: There is no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yong Chen, BM BCh, Chief Physician, Department of Thyroid Surgery, Affiliated Hospital of Chengde Medical University, No. 36 Nanyingzi Street, Shuangqiao District, Chengde 067000, Hebei Province, China. chenyong2021@yeah.net
Received: September 16, 2021 Peer-review started: September 16, 2021 First decision: October 18, 2021 Revised: October 19, 2021 Accepted: December 3, 2021 Article in press: December 3, 2021 Published online: January 14, 2022
ARTICLE HIGHLIGHTS
Research background
Fine-needle aspiration cytology (FNAC) can offer further cytological diagnostic support for lymph nodes with suspicious ultrasound (US) results.
Research motivation
Fine-needle aspiration of thyroglobulin (FNA-Tg) reportedly has a relatively high diagnostic value in lymph node metastasis and recurrence of differentiated thyroid carcinoma.
Research objectives
We explore and describe the value of FNA-Tg combined with US-guided FNAC to diagnose cervical lymph node metastasis in patients with thyroid carcinoma.
Research methods
A total of 209 pathologically diagnosed thyroid carcinoma patients who visited the Thyroid Surgery Department of the Hospital were selected.
Research results
The sensitivity and specificity of US-guided FNAC, FNA-Tg, and US-guided FNAC + FNA-Tg were 85.48% and 90.59%, 83.06% and 87.06%, and 96.77% and 91.76%, respectively.
Research conclusions
Combined with US-guided FNAC, it is significantly improved.
Research perspectives
The detection process and threshold setting lacked unified standards.
