Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 26, 2021; 9(33): 10116-10125
Published online Nov 26, 2021. doi: 10.12998/wjcc.v9.i33.10116
Clinical and electroencephalogram characteristics and treatment outcomes in children with benign epilepsy and centrotemporal spikes
Rui-Hua Chen, Bing-Fei Li, Jian-Hua Wen, Chun-Lan Zhong, Ming-Ming Ji
Rui-Hua Chen, Department of Children’s Neurology, Ganzhou Maternal and Child Health Hospital, Ganzhou 341000, Jiangxi Province, China
Bing-Fei Li, Chun-Lan Zhong, Ming-Ming Ji, Department of Pediatrics, Ganzhou Maternal and Child Health Hospital, Ganzhou 341000, Jiangxi Province, China
Jian-Hua Wen, Department of Pediatrics, Ningdu County People's Hospital, Ganzhou 341000, Jiangxi Province, China
Author contributions: Chen RH and Li BF designed this retrospective study; Chen RH wrote the paper; Chen RH, Li BF, Wen JH, Zhong CL, and Ji MM were responsible for sorting the data.
Institutional review board statement: This study was approved by the Ganzhou Maternal and Child Health Hospital Medical Ethics Committee.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: This is no conflict of interest to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Bing-Fei Li, BMed, Chief Physician, Department of Pediatrics, Ganzhou Maternal and Child Health Hospital, No. 106 Dagong Road, Zhanggong District, Ganzhou 341000, Jiangxi Province, China.
Received: July 6, 2021
Peer-review started: July 6, 2021
First decision: July 26, 2021
Revised: August 8, 2021
Accepted: August 27, 2021
Article in press: August 27, 2021
Published online: November 26, 2021

Epilepsy is a syndrome characterized by transient, rigid, paroxysmal, and repetitive central nervous system dysfunction. Prevention, control, and improvement of cognitive and behavioral dysfunction are of great significance for improving the patients’ intellectual development and quality of life. Electroencephalograms (EEG) can predict an accelerated decline in cognitive function.


To determine the clinical and EEG characteristics and treatment results of benign epilepsy in spiking children.


A total of 106 cases of benign epilepsy in children with myocardial spines treated at our hospital from January 2017 to January 2020 were selected. Differences in clinical data and EGG characteristics between treatment-effective/-ineffective patients were analyzed, and children’s intellectual development before and after treatment evaluated using the Gesell Development Diagnostic Scale.


EEG showed that the discharge proportion in the awake and sleep periods was 66.04%, and the peak/peak discharge was mainly single-sided, accounting for 81.13%, while the discharge generalization accounted for 31.13%. There was no significant difference in any of these variables between sexes and ages (P > 0.05). The proportion of patients with early onset (< 5 years old) and seizure frequency > 3 times/half a year was 40.00% and 60.00%, respectively; the incidence rate and seizure frequency in the younger age group (< 5 years old) were significantly higher than those in the treatment-effective group (P < 0.05), while the discharge index was significantly lower than that in the treatment-effective group (P < 0.05). The discharge index was negatively correlated with fine motor skill and language development (r = -0.274 and -0.247, respectively; P < 0.05), but not with the rest (P > 0.05). Logistic regression analysis showed that low age onset (< 5 years old) and seizure frequency were the factors affecting ineffective-treatment of benign epilepsy in children (odds ratio = 11.304 and 5.784, respectively; P < 0.05). The discharge index of the responsive group after treatment was significantly lower than that of the unresponsive group (P < 0.05). However, there was no significant difference between groups after treatment in gross and fine motor skills, adaptability, language, and personal social development (P > 0.05).


The EEG of children with benign epilepsy due to spinal wave in central time zone has characteristic changes, and the therapeutic effect is influenced by age of onset and attack frequency.

Keywords: Centrotemporal spikes, Benign epilepsy, Children, Electroencephalogram, Therapeutic effect

Core Tip: The electroencephalogram of children with benign epilepsy with centrotemporal spikes has characteristic changes, and the therapeutic effect is affected by the age and attack frequency of the children at the time of onset.