Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 26, 2021; 9(24): 7237-7244
Published online Aug 26, 2021. doi: 10.12998/wjcc.v9.i24.7237
Secondary peripheral T-cell lymphoma and acute myeloid leukemia after Burkitt lymphoma treatment: A case report
Li Huang, Can Meng, Dan Liu, Xiang-Jun Fu
Li Huang, Can Meng, Dan Liu, Xiang-Jun Fu, Department of Hematology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou 570311, Hainan Province, China
Author contributions: Huang L, Meng C and Liu D gathered the clinical information and drafted the manuscript; Fu XJ approved the final diagnosis and formulated the therapeutic strategies; All authors critically revised and gave the final approval of the manuscript.
Supported by Medical and Health Research Project of Hainan Province, No. 20A200013.
Informed consent statement: Written informed consent was obtained from the patient to publish this manuscript and any accompanying images.
Conflict-of-interest statement: The authors declared no potential conflicts of interest concerning the research, authorship and/or publication of this article.
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Corresponding author: Xiang-Jun Fu, Department of Hematology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, No. 19 Xiuhua Road, Xiuying District, Haikou 570311, Hainan Province, China.
Received: April 16, 2021
Peer-review started: April 16, 2021
First decision: April 27, 2021
Revised: May 25, 2021
Accepted: July 5, 2021
Article in press: July 5, 2021
Published online: August 26, 2021

Multiple primary cancer refers to more than one synchronous or sequential cancer in the same individual. Multiple primary cancer always presents as solid cancer or acute myeloid leukemia (AML) secondary to lymphoma. Here, we report a rare case of secondary peripheral T-cell lymphoma and AML after Burkitt lymphoma treatment.


A 54-year-old female patient was admitted to our hospital complaining of edema on her left lower limb. Physical examination revealed multiple superficial lymphadenectasis on her neck and pelvis. Color ultrasonography examination showed multiple uterine fibroids and a solid mass at the lower left side of the abdomen. Pathological biopsy revealed Burkitt lymphoma. After three hyper-CVAD (A + B) regimens, she achieved complete remission. Two years later, lymphadenectasis reoccurred. A relevant biopsy confirmed the diagnosis of peripheral T-cell lymphoma, which was accompanied by gastrointestinal invasion and hemocytopenia. Meanwhile, bone marrow examination revealed AML. On the second day of scheduled treatment, she developed gastrointestinal bleeding, peptic ulcers, and hemorrhagic shock and was critically ill. She was then discharged from the hospital due to financial concerns.


This is the first report of secondary peripheral T-cell lymphoma and AML after Burkitt lymphoma treatment with heterochronous and synchronal multiple primary cancers.

Keywords: Burkitt lymphoma, Peripheral T-cell lymphoma, Acute myeloid leukemia, Multiplicity carcinoma, Positron emission tomography-computed tomography, Case report

Core Tip: Frequently, secondary malignancies are not identified in a timely manner or are misdiagnosed. Literature indicates that secondary malignancies occur sporadically and spread gradually. The survival time for secondary cancer depends on the extent of tumor lesions than the number of tumors. This paper presents a rare case of secondary cancer to provide a complete understanding to the medical staff allowing them to make early diagnoses and initiate rational and integrated treatments to prolong the survival time and improve the prognosis.