Case Report
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 6, 2020; 8(3): 606-613
Published online Feb 6, 2020. doi: 10.12998/wjcc.v8.i3.606
Clinicopathologic characteristics of prostatic stromal sarcoma with rhabdoid features: A case report
Rong-Gang Li, Jun Huang
Rong-Gang Li, Department of Pathology, Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yat-Sen University, Jiangmen 529030, Guangdong Province, China
Jun Huang, Department of Urology, Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yat-Sen University, Jiangmen 529030, Guangdong Province, China
Author contributions: Li R was the diagnosing pathologist, conceived of and designed the report, and collected and prepared the images; Huang J was the treating urology surgeon and prepared the draft and final version of the manuscript; all authors have read and approved the final manuscript.
Informed consent statement: The patient involved in this study gave written informed consent authorizing the use and disclosure of his protected health information. The study protocol was approved without restrictions by the Medical Ethics Committee of the Institute of Jiangmen Central Hospital.
Conflict-of-interest statement: The authors have no conflicts of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Jun Huang, MD, Associate Professor, Attending Doctor, Surgeon, Department of Urology, Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yat-Sen University, Haipang Street 23, Pengjiang District, Jiangmen 529030, Guangdong Province, China.
Received: December 7, 2019
Peer-review started: December 7, 2019
First decision: December 23, 2019
Revised: December 27, 2019
Accepted: January 8, 2020
Article in press: January 8, 2020
Published online: February 6, 2020

Prostatic stromal sarcoma presenting with rhabdoid features is extremely rare, and only four cases have been reported in the English-language literature to date. Accordingly, there is no absolute definition of this group of tumors as yet, and our overall understanding of its morphological features, therapeutic regimen and prognosis is limited.


A 34-year-old male patient was referred to our hospital to address a 2-mo history of hematuria and progressive dysuria. Pelvic computed tomography scan revealed a 6.0 cm × 5.2 cm × 7.2 cm mass in the prostate, with bladder invasion. The patient underwent transurethral prostatectomy as upfront therapy. He refused further treatment and died of uncontrollable tumor growth 3 mo after surgery. Pathology analysis revealed the stroma to be pleomorphic, with a huge number of atypical spindle cells. Rhabdomyoblastic cells, with abundant eosinophilic cytoplasm, were detected. The spindle cells were positive for vimentin, INI1 and β-catenin, and the rhabdomyoblastic cells were positive for MyoD1, myogenin and INI1. The spindle cells and epithelial cells were sporadically positive for P53.


The prostatic stromal sarcoma tumor was immunoreactive for β-catenin, suggesting a role for the Wnt/β-catenin pathway in this tumor type.

Keywords: Prostatic stromal tumor, Rhabdoid features, Morphology, Immunohistochemistry, Prostate, Tumorigenesis, Case report

Core tip: An extremely rare case of prostatic stromal sarcoma is presented. The rhabdoid component represented only a minor part of the tumor, as revealed by pathology study. Detailed diagnostic information on this rare tumor type has been reported in the literature, although the molecular pathogenesis remains largely unknown. The β-catenin immunoreactivity of the tumor in our case suggests that the tumorigenesis process may involve the Wnt pathway.