Published online Mar 6, 2024. doi: 10.12998/wjcc.v12.i7.1227
Peer-review started: November 22, 2023
First decision: December 23, 2023
Revised: February 2, 2024
Accepted: January 29, 2024
Article in press: January 29, 2024
Published online: March 6, 2024
Despite being one of the most prevalent sleep disorders, obstructive sleep apnea hypoventilation syndrome (OSAHS) has limited information on its immunologic foundation. The immunological underpinnings of certain major psychiatric di
To investigate the immune cells' association with OSAHS via genetic methods, guiding future clinical research.
A comprehensive two-sample mendelian randomization study was conducted to investigate the causal relationship between immune cell characteristics and OS
Following false discovery rate (FDR) correction, no statistically significant effect of OSAHS on immunophenotypes was observed. However, two lymphocyte subsets were found to have a significant association with the risk of OSAHS: Basophil %CD33dim HLA DR- CD66b- (OR = 1.03, 95%CI = 1.01-1.03, P < 0.001); CD38 on IgD+ CD24- B cell (OR = 1.04, 95%CI = 1.02-1.04, P = 0.019).
This study shows a strong link between immune cells and OSAHS through a gene approach, thus offering direc
Core Tip: Our comprehensive bidirectional mendelian randomization analysis has revealed causal links between various immunophenotypes and obstructive sleep apnea-hypopnea syndrome (OSAHS), shedding light on the intricate web of relationships between OSAHS and the immune system.