Case Report
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 26, 2024; 12(18): 3529-3533
Published online Jun 26, 2024. doi: 10.12998/wjcc.v12.i18.3529
Laryngeal leiomyoma: A case report and review of literature
Yu Wu, Jing-Man Li, Tian-Jiao Zhang, Xin Wang
Yu Wu, Jing-Man Li, Tian-Jiao Zhang, Xin Wang, Department of Otolaryngology, Head and Neck Surgery, The First Hospital of Jilin University, Changchun 130000, Jilin Province, China
Author contributions: Wu Y and Wang X wrote the main manuscript text; Li JM revised the manuscript; Zhang TJ prepared figures. All authors reviewed the manuscript.
Supported by National Natural Science Foundation of China, No. 82071031.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare no conflicts of interest.
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Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Xin Wang, PhD, Doctor, Department of Otolaryngology, Head and Neck Surgery, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130000, Jilin Province, China.
Received: October 23, 2023
Revised: February 7, 2024
Accepted: May 9, 2024
Published online: June 26, 2024
Processing time: 239 Days and 2.9 Hours

Leiomyomas (LMs) are mesenchymal tumors that arise from smooth muscle cells. LMs most commonly arise in organs with an abundance of smooth muscle such as the uterus and gastrointestinal tract. Conversely, LMs are rarely detected in the head and neck region. In this study, we report a rare case of laryngeal LM (LLM) and summarized the clinical characteristics of reported LLMs to help clinicians better understand this rare disease and improve its diagnosis, treatment, and postoperative course.


A 49-year-old man was admitted to our ENT outpatient clinic with a chief complaint of pharynx discomfort for 2 months. Laryngoscopy performed under topical anesthesia revealed a solitary, pink mass at the tubercle of epiglottis. Surgery via laryngeal endoscopy was performed under general anesthesia, and the lesion was excised easily. Positive immunohistochemical staining for desmin and smooth-muscle actin indicated a smooth muscle origin and the diagnosis was laryngeal leiomyoma. After surgery, the patient’s condition was stable, and he was discharged 2 d after surgery. During the 1-year postoperative period, the patient’s condition remained stable without evidence of recurrence.


Surgical resection is the preferred treatment for LLMs, its early diagnosis and differential diagnosis have important clinical significance.

Keywords: Leiomyoma, Larynx, Smooth tumor, Endoscopic surgery, Case report

Core Tip: We present a rare case of laryngeal leiomyoma (LLM) admitted to our institution, while also providing a comprehensive review and synthesis of the clinical characteristics associated with reported LLMs. Our aim is to enhance clinicians' comprehension of this uncommon disease, thereby facilitating improved diagnosis, treatment strategies, and postoperative patient recovery.