Alzaman N. Multifocal papillary thyroid cancer in Graves’ disease: A case report. World J Clin Cases 2023; 11(35): 8379-8384 [PMID: 38130618 DOI: 10.12998/wjcc.v11.i35.8379]
Corresponding Author of This Article
Naweed Alzaman, MD, Assistant Professor, Department of Internal Medicine, Taibah University College of Medicine, Janadah Bin Umayyah Road, Tayba 42353, Al-Madinah al-Munawwarah, Saudi Arabia. nzaman@taibahu.edu.sa
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Dec 16, 2023; 11(35): 8379-8384 Published online Dec 16, 2023. doi: 10.12998/wjcc.v11.i35.8379
Multifocal papillary thyroid cancer in Graves’ disease: A case report
Naweed Alzaman
Naweed Alzaman, Department of Internal Medicine, Taibah University College of Medicine, Tayba 42353, Al-Madinah al-Munawwarah, Saudi Arabia
Author contributions: Alzaman N confirms sole responsibility for the following: study conception and design, data collection, analysis, interpretation of results and manuscript preparation.
Informed consent statement: Informed written consent was obtained from the patient for the publication of this report and any accompanying images.
Conflict-of-interest statement: All the author declares that he has no conflict of interest to disclose.
CARE Checklist (2016) statement: The author has read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Naweed Alzaman, MD, Assistant Professor, Department of Internal Medicine, Taibah University College of Medicine, Janadah Bin Umayyah Road, Tayba 42353, Al-Madinah al-Munawwarah, Saudi Arabia. nzaman@taibahu.edu.sa
Received: August 31, 2023 Peer-review started: August 31, 2023 First decision: October 9, 2023 Revised: November 4, 2023 Accepted: December 5, 2023 Article in press: December 5, 2023 Published online: December 16, 2023
Abstract
BACKGROUND
Thyroid cancer is not commonly observed in patients with Graves’ disease (GD). The presence of thyroid nodules in GD is not uncommon. However, a link between these two entities has been reported. Herein, we report the case of a patient with GD and thyroid cancer in Saudi Arabia, which has not been reported previously in our region.
CASE SUMMARY
A 26-year-old male patient with GD, receiving carbimazole for 2 years, presented to our hospital. His hyperthyroidism was controlled clinically and biochemically. On clinical examination, he was found to have a left-sided thyroid nodule. Ultrasound revealed a 2.6 cm hypoechoic nodule with high vascularity. He was then referred for fine needle aspiration which showed that the nodule was highly suspicious for malignancy. The patient underwent total thyroidectomy and was diagnosed with multifocal classical micropapillary thyroid cancer. Post thyroidectomy he received radioactive iodine ablation along with levothyroxine replacement therapy.
CONCLUSION
Careful preoperative assessment and thyroid gland ultrasound might assist in screening and diagnosing thyroid cancer in patients with GD.
Core Tip: Thyroid cancer in male patients with Graves’ disease (GD) is rare. We report the first case of multifocal micropapillary thyroid cancer in a young male patient with GD in Saudi Arabia, which was detected by careful clinical examination followed by ultrasonographic evaluation of the nodule.
