Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 26, 2023; 11(3): 692-699
Published online Jan 26, 2023. doi: 10.12998/wjcc.v11.i3.692
Imaging features of retinal hemangioblastoma: A case report
Xin Tang, Hai-Ming Ji, Wen-Wen Li, Zhong-Xiang Ding, Sheng-Li Ye
Xin Tang, Department of Radiology, Hangzhou Wuyunshan Hospital, Hangzhou Health Promotion Research Institute, Hangzhou 310008, Zhejiang Province, China
Hai-Ming Ji, Department of Radiology, Liangzhu Hospital, Hangzhou 311112, Zhejiang Province, China
Wen-Wen Li, Department of Radiology, Jingmen No.1 People’s Hospital, Jingmen 448000, Hubei Province, China
Zhong-Xiang Ding, Department of Radiology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, Zhejiang Province, China
Sheng-Li Ye, Department of Radiology, Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College, Hangzhou 310022, Zhejiang Province, China
Author contributions: Tang X, Ding ZX and Ye SL designed the research; Tang X, Ji HM and Ding ZX performed the research; Tang X, Ji HM and Li WW contributed new reagents/analytic tools; Tang X, Li WW and Ye SL analyzed the data; Tang X and Ding ZX wrote the paper; all authors contributed to the article and approved the submitted version.
Supported by the National Natural Science Foundation of China, No. 81871337; and the Natural Science Foundation of Zhejiang Province, No. LY16H180007.
Informed consent statement: The study participants, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All authors declare no conflict of interest, financial or otherwise.
CARE Checklist (2016) statement: The CARE Checklist was done according to the Journal.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sheng-Li Ye, MD, Professor, Department of Radiology, Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College, No. 848 Dongxin Road, Hangzhou 310022, Zhejiang Province, China. 532382048@qq.com
Received: November 24, 2022
Peer-review started: November 24, 2022
First decision: December 13, 2022
Revised: December 22, 2022
Accepted: January 5, 2023
Article in press: January 5, 2023
Published online: January 26, 2023
Processing time: 63 Days and 6.9 Hours
Abstract
BACKGROUND

Hemangioblastoma typically occurs in the cerebellum, spinal cord, and central nervous system. However, in rare cases, it could occur in the retina or optic nerve. The prevalence of retinal hemangioblastoma is 1 in 73080, and it occurs either alone or as the manifestation of von Hippel Lindau (VHL) disease. Here, we reported a rare case with the imaging features of retinal hemangioblastoma without VHL syndrome, along with the relevant literature review.

CASE SUMMARY

A 53-year-old man had progressive swelling, pain and blurred vision in the left eye without obvious inducement for 15 d. Ultrasonography revealed a possible optic nerve head melanoma. Computed tomography (CT) showed punctate calcification on the posterior wall of the left eye ring and small patchy soft tissue density in the posterior part of the eyeball. Magnetic resonance imaging showed slightly hyperintense signal on T1-weighted images and slightly hypointense-to-isointense signal on T2-weighted images at the medial and posterior edges of the left eyeball, a significant enhancement was observed in the contrast-enhanced scans. Positron emission tomography/CT fusion images showed that the glucose metabolism of the lesion was normal. Pathology was consistent with hemangioblastoma.

CONCLUSION

Early identification of retinal hemangioblastoma based on imaging features is of great value for its personalized treatment.

Keywords: Ultrasound; Computed tomography; Magnetic resonance imaging; Positron emission tomography; Computed tomography; Case report

Core Tip: We reported a rare case of the imaging features of retinal hemangioblastoma without von Hippel Lindau syndrome, along with the relevant literature review. A 53-year-old man, who had progressive swelling, pain and blurred vision in the left eye without obvious inducement for 15 d. Ultrasonography revealed a possible optic nerve melanoma of the head. Computed tomography (CT) showed punctate calcification on the posterior wall of the left eye ring and small patchy soft tissue density in the posterior part of the eyeball. Magnetic resonance imaging showed slightly hyperintense on T1-weighted images and slightly hypointense-to-isointense on T2-weighted images at the medial and posterior edges of the left eyeball, a significant enhancement was observed after contrast-enhanced scans. positron emission tomography/CT fusion images showed that the glucose metabolism of the lesion was normal. Pathology was consistent with hemangioblastoma. Early identification of retinal hemangioblastoma by imaging features is of great value for its personalized treatment.