Published online May 16, 2023. doi: 10.12998/wjcc.v11.i14.3295
Peer-review started: January 7, 2023
First decision: March 24, 2023
Revised: April 2, 2023
Accepted: April 12, 2023
Article in press: April 12, 2023
Published online: May 16, 2023
Pulmonary mucormycosis is a rare but life-threatening invasive fungal infection that mostly affects immunocompromised patients. This disease usually develops acutely and progresses rapidly, often leading to a poor clinical prognosis. Chronic pulmonary mucormycosis is highly unusual in immunocompetent patients.
A 43-year-old man, who was a house improvement worker with a long history of occupational dust exposure, presented with an irritating cough that had lasted for two months. The patient was previously in good health, without dysglycemia or any known immunodeficiencies. Chest computed tomography revealed a mass in the left lower lobe, measuring approximately 6 cm in diameter, which was suspected to be primary lung carcinoma complicated with obstructive pneu
This article reports a rare case of chronic pulmonary mucormycosis caused by Rhizopus microsporus in a middle-aged male without dysglycemia or immunodeficiency. The patient's surgical outcome was excellent, reaffirming that surgery remains the cornerstone of pulmonary mucormycosis treatment.
Core Tip: Pulmonary mucormycosis is a rare yet life-threatening invasive fungal infection that typically affects immunocompromised patients. In this report, we present a case of chronic pulmonary mucormycosis in a 43-year-old immunocompetent house improvement worker. The patient initially presented with an irritating cough and a solitary mass in the left lower lobe, which raised concerns of primary lung carcinoma. A successful thoracoscopic-assisted left lower lobectomy was performed, and subsequent metagenomic next-generation sequencing analysis and specialized pathological staining of surgical specimens suggested Rhizopus microsporus as the causative agent of the infection. During a six-month postoperative follow-up, no signs of recurrence were observed.