Published online Nov 26, 2022. doi: 10.12998/wjcc.v10.i33.12455
Peer-review started: July 18, 2022
First decision: September 25, 2022
Revised: October 4, 2022
Accepted: October 31, 2022
Article in press: October 31, 2022
Published online: November 26, 2022
The symptoms of disseminated strongyloidiasis are not typical, and it is difficult for clinicians to identify strongyloidiasis in some non-endemic areas. We report a 70-year-old woman who was diagnosed with Guillain-Barré syndrome due to autonomic disturbance, symmetrical bulbar palsy, and lower-motor-nerve damage in the extremities; her symptoms continued to worsen after hormone and immunoglobulin therapy. Later, parasitic larvae were found in the patient’s gastric fluid, and metagenomic next generation sequencing (mNGS) detection of bronchoalveolar-lavage fluid also found a large number of Strongyloides round
Core Tip: Metagenomic next-generation sequencing (mNGS) has a high sensitivity in identifying pathogen species. As a new pathogenic detection method, it plays an irreplaceable role in unexplained infectious diseases. It can provide important information for clinicians to identify new pathogens, non-tuberculosis mycobacteria and parasites. With the continuous improvement of clinical laboratory diagnostic technology, mNGS has been used more and more widely in clinical practice, and has become the main means to identify parasites in non-endemic areas.