Letter to the Editor
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 6, 2022; 10(28): 10387-10390
Published online Oct 6, 2022. doi: 10.12998/wjcc.v10.i28.10387
Tumor invasion front in oral squamous cell carcinoma
Juan Carlos Cuevas-González, Maria Veronica Cuevas-González, Leon Francisco Espinosa-Cristobal, Alejandro Donohue Cornejo
Juan Carlos Cuevas-González, Leon Francisco Espinosa-Cristobal, Alejandro Donohue Cornejo, Institute of Biomedical Sciences, Universidad Autonoma de Ciudad Juarez, Juarez 32320, Chihuahua, Mexico
Maria Veronica Cuevas-González, Faculty of Health Sciences Valle de las Palmas, Universidad Autonoma de Baja California, Tijuana 21480, Baja California, Mexico
Author contributions: Cuevas-Gonzalez MV wrote the letter; Cuevas-Gonzalez JC and Donohue Cornejo A performed the histopathological analyses; Espinosa Cristóbal LF revised the letter; All authors have read and approved the final manuscript.
Conflict-of-interest statement: All the Authors have no conflict of interest related to the manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Alejandro Donohue Cornejo, PhD, Academic Research, Institute of Biomedical Sciences, Universidad Autonoma de Ciudad Juarez, Av. Benjamín Franklin No. 4650, Zona Pronaf Condominio La Plata, Juarez 32320, Chihuahua, Mexico. adonohue@uacj.mx
Received: June 6, 2022
Peer-review started: June 6, 2022
First decision: August 4, 2022
Revised: August 13, 2022
Accepted: August 30, 2022
Article in press: August 30, 2022
Published online: October 6, 2022

Oral squamous cell carcinoma is a neoplasm that originates from the epithelial mucosa. It is usually more frequent between the fifth and sixth decades of life, and more than 90% of carcinomas of the oral cavity are squamous cell carcinoma. It is an invasive neoplasia with a significant recurrence rate; 40% of patients present with metastases in the cervical lymph nodes at the time of diagnosis. The tumor invasion front is a characteristic of tumor growth, which can be infiltrative or noninvasive. The histopathological parameters examined include the number of mitoses, depth of the tumor, invasion pattern, degree of keratinization, and nuclear pleomorphism. For the pathologist, these parameters are routinely evaluated but are not reported to the treating physician in all cases, which we consider to be useful information when determining the therapeutic route.

Keywords: Oral squamous cell carcinoma, Invasive neoplasia, Therapeutic route, Life, Tumor growth, Pleomorphism

Core Tip: The histopathological parameters of the tumor invasion front are evaluated by the pathologist at the diagnosis of squamous cell carcinoma. This information is not part of the microscopic description that the treating physician receives in all cases. Thus, we propose the evaluation and reporting of the tumor invasion front, thus providing the medical doctor with more objective criteria when establishing the therapeutic route for each patient.