Case Report
Copyright ©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Clin Cases. Jul 16, 2013; 1(4): 143-145
Published online Jul 16, 2013. doi: 10.12998/wjcc.v1.i4.143
Giant hibernoma of the thoracic pleura and chest wall
Dawn E Jaroszewski, Giovanni De Petris
Dawn E Jaroszewski, Division of Cardiothoracic Surgery, Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ 85054, United States
Giovanni De Petris, Department of Pathology, Mayo Clinic Arizona, Phoenix, AZ 85054, United States
Author contributions: Both De Petris G and Jaroszewski DE were physicians in the care of the patient, performed pathological examinations and participated in writing of this manuscript; Jaroszewski DE performed the surgery on the patient.
Correspondence to: Dawn E Jaroszewski, MD, Associate Professor of Surgery, Division of Cardiothoracic Surgery, Department of Surgery, Mayo Clinic Arizona, 5777 E Mayo Boulevard, Phoenix, AZ 85054, United States.
Telephone: +1-480-3422270 Fax: +1-480-3422269
Received: March 20, 2013
Revised: May 18, 2013
Accepted: June 1, 2013
Published online: July 16, 2013

Hibernoma is a rare tumor containing prominent brown adipocytes that resemble normal brown fat. Brown fat (versus white fat) is predominantly found in hibernating mammals and infants. Brown fat adipocytes contain a higher number of small lipid droplets and a much denser concentration of mitochondria. The tumor can occur in a variety of locations however the extremities, followed by the head and neck, have been the most common sights. All variants of hibernoma described have followed a benign course with the majority presenting as a small, lobulated, nontender lesions. We present a case of a giant hibernoma arising from the pleura which invaded the intra and extra-thoracic chest.

Keywords: Hibernoma, Lipoma, Thoracic wall, Pleural neoplasm, Thoracic neoplasms

Core tip: Hibernomas are rare tumors containing brown fat. They are uncommonly located on the chest or pleura. Differentiation for other malignant tumors requires histologic evaluation. Surgical excision is the treatment of choice. Treatment of large and symptomatic hibernomas is surgical excision. This is curative in the majority of patients with the exception of a rare case reported having recurrence after unclear resection margins.