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World J Clin Cases. Apr 16, 2013; 1(1): 31-33
Published online Apr 16, 2013. doi: 10.12998/wjcc.v1.i1.31
Published online Apr 16, 2013. doi: 10.12998/wjcc.v1.i1.31
Low ADAMTS-13 in plavix induced thrombotic thrombocytopenic purpura
Long Bao Cao, Christopher Jones, Assad Movahed, Department of Cardiovascular Sciences, Brody School of Medicine, East Carolina University, Greenville, NC 27834, United States
Author contributions: Cao LB, Jones C and Movahed A contributed to the manuscript writing and revision.
Supported by The “East Carolina Heart Institute”
Correspondence to: Assad Movahed, MD, Department of Cardiovascular Sciences, Brody School of Medicine, East Carolina University, East Carolina Heart Institute, 115 Heart Drive, Mail Stop 651, Greenville, NC 27834, United States. movaheda@ecu.edu
Telephone: +1-832-3731447 Fax: +1-252-7447724
Received: October 30, 2012
Revised: December 17, 2012
Accepted: January 5, 2013
Published online: April 16, 2013
Revised: December 17, 2012
Accepted: January 5, 2013
Published online: April 16, 2013
Abstract
Thrombotic thrombocytopenia purpura (TTP) was first described in 1924 as a “pathologic alteration of the microvasculature, with detachment or swelling of the endothelium, amorphous material in the sub-endothelial space, and luminal platelet aggregation leading to compromise of the microcirculation”. Ticlopidine induced TTP has been highly associated with autoimmune induced reduction in ADAMTS-13 activity. These findings, to a lesser extent, have also been found in clopidogrel induced TTP. We report a case of clopidogrel associated TTP in a patient that presented with acute stroke, renal failure, and non-ST elevation myocardial infarction.