Novel biomarkers of the Framingham risk score in patients with depression: A cross-sectional study

Table 1 Sociodemographic and clinical characteristics of healthy controls and patients with depression, n (%)

Characteristics	HC (n = 279)	MD (n = 164)	Statistics	P value
Age (year), mean ± SD	44.1 ± 8.0	44.6 ± 6.7	-1.130	0.258
Gender
Male	98 (35.1)	59 (36.0)	0.033	0.857
Female	181 (64.9)	105 (64.0)	-	-
Smoking
No	7 (2.5)	23 (14.0)	21.694	< 0.001
Yes	272 (97.5)	141 (86.0)	-	-
SBP (mmHg), mean ± SD	105.3 ± 13.9	122.0 ± 17.7	-9.974	< 0.001
DBP (mmHg), mean ± SD	72.2 ± 8.3	79.2 ± 11.0	-7.036	< 0.001
Hypertension
Yes	10 (3.6)	30 (18.3)	27.203	< 0.001
No	269 (96.4)	134 (81.7)	-	-
Diabetes
Yes	3 (1.1)	9 (5.5)	7.751	0.005
No	276 (98.9)	155 (94.5)	-	-
Illness duration, month, mean ± SD	-	68.8 ± 75.5	-	-
Medication duration, month, mean ± SD	-	44.8 ± 57.2	-	-
Attack times, mean ± SD	-	1.9 ± 1.1	-	-
Family history of depression	-	-	-	-
Yes	-	-	-	-
No	-	-	-	-
FRS (%), mean ± SD	2.3 (2.1)	5.3 ± 5.3	-8.538	< 0.001

HC: Healthy controls; MD: Major depression; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; FRS: Framingham risk score.

Table 2 Significant regression correlations between the Framingham risk score and all the factors in patients with depression

Characteristics	B (95%CI)	Beta	t	P value
Illness duration	0.02 (0.01-0.03)	0.262	2.628	0.009
Medication duration	-0.02 (-0.04-0.00)	-0.189	-1.875	0.063
Attack times	-0.43 (-1.26-0.40)	-0.088	-1.029	0.305
Family history of psychosis	2.29 (0.27-4.32)	0.156	2.235	0.027
TSH	0.23 (-0.27-0.74)	0.062	0.904	0.367
Alb	0.10 (-0.17-0.38)	0.053	0.705	0.642
TBIL	0.03 (-0.11-0.17)	0.035	0.466	0.642
TG	2.63 (1.69-3.56)	0.415	5.560	< 0.001
UA	0.01 (0.00-0.02)	0.155	2.105	0.037

TSH: Thyroid stimulating hormone; Alb: Albumin; TBIL: Total bilirubin; TG: Triglycerides; UA: Uric acid.