Case Control Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Aug 19, 2025; 15(8): 106303
Published online Aug 19, 2025. doi: 10.5498/wjp.v15.i8.106303
Novel biomarkers of the Framingham risk score in patients with depression: A cross-sectional study
Li-Na Zhou, Yan Mao, Bai-Jia Li, Xian-Cang Ma, Wei Wang
Li-Na Zhou, Bai-Jia Li, Xian-Cang Ma, Wei Wang, Department of Psychiatry, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Yan Mao, Department of Psychosomatic Medicine, The Fifth Hospital of Yulin, Yulinshi 719000, Shaanxi Province, China
Author contributions: Zhou LN, Mao Y, and Li BJ obtained and interpreted the data, drafted the article, and reviewed the final version; Ma XC, Wang W reflected on the design and recruitment of participants; Zhou LN, Mao Y, Li BJ, Ma XC, and Wang W conducted the conception and design of the research; and all authors thoroughly reviewed and endorsed the final manuscript.
Supported by the National Natural Science Foundation of China, No. 82301737.
Institutional review board statement: This study was approved by the Medical Ethics Committee of the First Affiliated Hospital of Xi’an Jiaotong University, approval No. XJTUIAF2018 LSK-076.
Informed consent statement: All written informed consent was obtained from all participants.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The data underlying this study are not publicly available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Na Zhou, Department of Psychiatry, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277 West Yanta Street, Xi’an 710061, Shaanxi Province, China. zhoulinapsy@xjtu.edu.cn
Received: February 26, 2025
Revised: May 6, 2025
Accepted: June 23, 2025
Published online: August 19, 2025
Processing time: 163 Days and 18.4 Hours
Core Tip

Core Tip: This study evaluated the Framingham risk score of coronary heart disease (CHD) in patients with depression and detected their cardiovascular biomarkers. It was found that the risk of CHD in patients with depression was increased, and the levels of new cardiovascular biomarkers, triglyceride and uric acid, were related to the risk of CHD in patients with depression.