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World J Psychiatry. Sep 19, 2026; 16(9): 120241
Published online Sep 19, 2026. doi: 10.5498/wjp.120241
Published online Sep 19, 2026. doi: 10.5498/wjp.120241
Endocrine psychiatric comorbidity in metabolic disorders: Integrative mechanisms and traditional Chinese medicine
Miao Yan, School of Medicine and Pharmacy, College of Science and Technology Changchun, Changchun 130600, Jilin Province, China
Han Yang, School of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130021, Jilin Province, China
Di Cui, School of Basic Medicine, Changchun University of Chinese Medicine, Changchun 130117, Jilin Province, China
Yi-Shuo Zhang, School of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun 130117, Jilin Province, China
Author contributions: Yan M, Yang H, and Cui D conceived and designed the study, performed the statistical analysis, and wrote the manuscript; Zhang YS collected and processed the data, conducted literature research, and critically revised the manuscript for important intellectual content. All authors reviewed and approved the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Yi-Shuo Zhang, School of Pharmaceutical Sciences, Changchun University of Chinese Medicine, No. 1035 Boshuo Road, Jingyue National High-Tech Industrial Development Zone, Changchun 130117, Jilin Province, China. 202400904@ccucm.edu.cn
Received: March 13, 2026
Revised: April 17, 2026
Accepted: May 29, 2026
Published online: September 19, 2026
Processing time: 163 Days and 21.4 Hours
Revised: April 17, 2026
Accepted: May 29, 2026
Published online: September 19, 2026
Processing time: 163 Days and 21.4 Hours
Core Tip
Core Tip: Endocrine-psychiatric comorbidity in metabolic disorders is conceptualised as a bidirectional, self-reinforcing state in which sleep and behavioural feasibility are clinically actionable leverage points that can shape metabolic trajectories. Traditional Chinese medicine is framed as adjunctive, module-targeted care, with pattern phenotyping used pragmatically for stratification rather than as a parallel diagnostic system. Credible integration requires paired metabolic and mental health endpoints, mediator tracking, and structured safety monitoring within an iterative care pathway.