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World J Psychiatry. Nov 19, 2026; 16(11): 124306
Published online Nov 19, 2026. doi: 10.5498/wjp.124306
Published online Nov 19, 2026. doi: 10.5498/wjp.124306
Research trends of ferroptosis and pyroptosis in depression: A bibliometric analysis
Ailipinai Yasen, Zhao-Dan Gan, Dan Zhen, Rehabilitation Medicine Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Meng-Ping Huang, Rui-Tao Hou, Cong-Hui Wei, Department of Rehabilitation Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, Jiangsu Province, China
Xin-Yu Zhang, School of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu 610199, Sichuan Province, China
Guang-Xu Xu, Department of Rehabilitation, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Co-corresponding authors: Guang-Xu Xu and Cong-Hui Wei.
Author contributions: Yasen A, Gan ZD, Huang MP, and Zhang XY conceived and designed the study and identified the research topic; Yasen A, Hou RT, and Zhen D performed data processing and statistical analysis; Yasen A, Gan ZD, and Huang MP contributed to data analysis and interpretation; and Yasen A drafted the manuscript and supervised the study. All authors revised and approved the final manuscript. Xu GX and Wei CH contributed equally to the overall direction and supervision of the project, and these collective contributions underlie their merit as co-corresponding authors.
AI contribution statement: No AI tools or services were used in the writing, editing, or preparation of this manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Corresponding author: Cong-Hui Wei, PhD, Department of Rehabilitation Medicine, The Affi
Received: June 11, 2026
Revised: July 30, 2026
Accepted: September 24, 2026
Published online: November 19, 2026
Processing time: 140 Days and 17.7 Hours
Revised: July 30, 2026
Accepted: September 24, 2026
Published online: November 19, 2026
Processing time: 140 Days and 17.7 Hours
Core Tip
Core Tip: This bibliometric analysis maps the global research landscape of ferroptosis- and pyroptosis-related mechanisms in depression. Pyroptosis-related research emerged earlier, whereas ferroptosis-related research has increased rapidly in recent years. Oxidative stress, neuroinflammation, iron metabolism, mitochondrial dysfunction, and targeted interventions are major themes. The findings identify leading contributors, evolving hotspots, and the need for integrated mechanistic and clinical studies to evaluate regulated cell death pathways as potential biomarkers and therapeutic targets for depression.