Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Sep 19, 2025; 15(9): 109175
Published online Sep 19, 2025. doi: 10.5498/wjp.v15.i9.109175
Anxiety and depression in recurrent implantation failure after frozen-thawed embryo transfer and efficacy of endometrial receptivity testing
Ya-Bin Guo, Bin Tang, Ling Zhang, Xue Wu, Zhi-Hua Huang
Ya-Bin Guo, Bin Tang, Ling Zhang, Xue Wu, Center of Reproductive Medicine, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City), Changde 415000, Hunan Province, China
Zhi-Hua Huang, Department of Neurology, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City), Changde 415000, Hunan Province, China
Author contributions: Guo YB designed the study, analyzed the data, and performed the experiments; Guo YB, Tang B, Zhang L, and Wu X collected the data; Guo YB and Huang ZH prepared the manuscript; and all authors read and approved the final manuscript.
Institutional review board statement: This study was approved by the Medical Ethics Committee of the First People’s Hospital of Changde city.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Hua Huang, Associate Chief Physician, Department of Neurology, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City), No. 818 Renmin Road, Changde 415000, Hunan Province, China. hzhgyb@163.com
Received: May 14, 2025
Revised: June 22, 2025
Accepted: July 15, 2025
Published online: September 19, 2025
Processing time: 104 Days and 2 Hours
Core Tip

Core Tip: Repeated implantation failures, i.e., three consecutive embryo transfer failures, occur in ≥ 20% of patients undergoing assisted conception, which not only imposes a huge economic burden on the patients but also brings about greater physical and psychological trauma. This study investigated the incidence of anxiety and depression in patients experiencing repeated implantation failures and analyzed factors influencing these conditions to propose a feasible and effective intervention model aimed at alleviating psychological distress and ultimately improving clinical pregnancy and birth rates.