Review
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Aug 19, 2025; 15(8): 108933
Published online Aug 19, 2025. doi: 10.5498/wjp.v15.i8.108933
Exosomal microRNAs in common mental disorders: Mechanisms, biomarker potential and therapeutic implications
Ya-Nan He, Hao-Hao Zhu, Zhen-He Zhou, Kan-Kan Qu
Ya-Nan He, Zhen-He Zhou, Department of Psychiatry, The Affiliated Mental Health Center of Jiangnan University, Wuxi 214151, Jiangsu Province, China
Hao-Hao Zhu, Kan-Kan Qu, Department of Pharmacy, The Affiliated Mental Health Center of Jiangnan University, Wuxi 214151, Jiangsu Province, China
Co-corresponding authors: Zhen-He Zhou and Kan-Kan Qu.
Author contributions: Zhou ZH provided financial support and approved the final version; Qu KK designed the review framework and performed critical appraisal of selected studies; He YN conducted the systematic literature search and drafted the manuscript; Zhu HH supervised the research and revised the intellectual structure; All authors approved the final submission.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kan-Kan Qu, MD, Doctor, Department of Pharmacy, The Affiliated Mental Health Center of Jiangnan University, No. 156 Qianrong Road, Binhu District, Wuxi 214151, Jiangsu Province, China. qukankan87@126.com
Received: April 27, 2025
Revised: June 3, 2025
Accepted: June 24, 2025
Published online: August 19, 2025
Processing time: 104 Days and 22.1 Hours
Core Tip

Core Tip: This synthesis highlights exosomal microRNAs as dual-functional tools bridging mechanistic insights into mental disorders and paving the way for personalized diagnostics/therapeutics. Focus on shared pathways (e.g., toll-like receptor 4, phosphatidylinositol 3-kinase/protein kinase B) may unify treatment strategies across diverse psychiatric conditions.