Lyu SC, Zhong GQ, Shi RJ, Sun Y, Li J, Li MS, Chen Y. Diamine oxidase as a biomarker for depression and disease activity in inflammatory bowel disease: A cross-sectional observational study. World J Psychiatry 2025; 15(8): 106971 [DOI: 10.5498/wjp.v15.i8.106971]
Corresponding Author of This Article
Ye Chen, MD, PhD, Professor, Department of Gastroenterology, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Gastroenterology, Nanfang Hospital, Southern Medical University, No. 1838 Baiyun Road North, Baiyun District, Guangzhou 510515, Guangdong Province, China. yechen@smu.edu.cn
Research Domain of This Article
Psychology, Clinical
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Psychiatry. Aug 19, 2025; 15(8): 106971 Published online Aug 19, 2025. doi: 10.5498/wjp.v15.i8.106971
Diamine oxidase as a biomarker for depression and disease activity in inflammatory bowel disease: A cross-sectional observational study
Su-Cong Lyu, Guo-Qiang Zhong, Run-Jie Shi, Yan Sun, Jin Li, Ming-Song Li, Ye Chen
Su-Cong Lyu, Ye Chen, Department of Gastroenterology, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Guo-Qiang Zhong, Run-Jie Shi, Yan Sun, Department of Gastroenterology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, Guangdong Province, China
Jin Li, Department of Gastroenterology, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen 518000, Guangdong Province, China
Ming-Song Li, Department of Gastroenterology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, Guangdong Province, China
Ye Chen, Integrative Microecology Clinical Center, Shenzhen Hospital, Southern Medical University, Shenzhen 518000, Guangdong Province, China
Author contributions: Chen Y, Li J, Li MS, and Sun Y designed the research study; Lyu SC, Zhong GQ, and Shi RJ performed the research.
Supported by National Natural Science Foundation of China, No. 82270581 and No. 82270546.
Institutional review board statement: This study was approved by the ethics committee and clinical trial registry of the Third Affiliated Hospital of Guangzhou Medical University (approval No. LCYJ-2022-015).
Informed consent statement: All participants completed informed consent forms.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The study dataset is available from the corresponding author at yechen@smu.edu.cn.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ye Chen, MD, PhD, Professor, Department of Gastroenterology, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Gastroenterology, Nanfang Hospital, Southern Medical University, No. 1838 Baiyun Road North, Baiyun District, Guangzhou 510515, Guangdong Province, China. yechen@smu.edu.cn
Received: March 23, 2025 Revised: June 2, 2025 Accepted: June 24, 2025 Published online: August 19, 2025 Processing time: 139 Days and 2.9 Hours
Core Tip
Core Tip: Few studies have explored the association between markers of intestinal barrier dysfunction and psychological symptoms in patients with inflammatory bowel disease (IBD). Our study revealed that serum diamine oxidase (DAO) levels were significantly elevated in IBD patients with moderate-to-severe psychological symptoms as compared to those with no or mild psychological symptoms. Furthermore, correlation analysis indicated that DAO was positively associated with depression and negatively associated with quality of life in IBD patients. Additionally, receiver operating characteristic curves confirmed that DAO is associated with clinical disease activity in patients with IBD. This study suggests the potential of DAO as a novel biomarker for predicting psychological symptoms and disease activity in IBD.
