Unveiling the invisible: How cutting-edge neuroimaging transforms adolescent depression diagnosis

doi:10.5498/wjp.v15.i5.102953

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Letter to the Editor

World J Psychiatry. May 19, 2025; 15(5): 102953
Published online May 19, 2025. doi: 10.5498/wjp.v15.i5.102953

Unveiling the invisible: How cutting-edge neuroimaging transforms adolescent depression diagnosis

Haewon Byeon

Haewon Byeon, Worker's Care and Digital Health Lab, Department of Future Technology, Korea University of Technology and Education, Cheonan 31253, South Korea

Author contributions: Byeon H contributed to this paper and was involved in data interpretation and writing the article.

Supported by Basic Science Research Program through the National Research Foundation of Korea Funded by the Ministry of Education, No. NRF- RS-2023-00237287.

Conflict-of-interest statement: No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Haewon Byeon, PhD, Associate Professor, Worker's Care and Digital Health Lab, Department of Future Technology, Korea University of Technology and Education, 1600 Chungjeol-Ro, Cheonan 31253, South Korea. bhwpuma@naver.com

Received: November 4, 2024
Revised: February 13, 2025
Accepted: February 24, 2025
Published online: May 19, 2025
Processing time: 178 Days and 4.5 Hours

Core Tip

Core Tip: Yu et al's research sheds light on adolescent major depressive disorder (MDD), focusing on the amygdala. The study explored neuroimaging biomarkers for diagnostics using resting-state functional magnetic resonance imaging to analyze functional connectivity (FC) in adolescents with MDD. It found reduced FC in the left inferior temporal gyrus and right lingual gyrus, alongside increased connectivity in Vermis-10. Support vector machines effectively distinguished MDD patients from healthy controls, highlighting reduced FC in the right lingual gyrus as a key marker. These findings suggest FC changes as reliable biomarkers, offering a non-invasive, accurate diagnostic approach for adolescent MDD.