Hippocampus protection from apoptosis by Baicalin in a LiCl-pilocarpine-induced rat status epilepticus model through autophagy activation
Bin Yang, Han-Yu Wen, Ting-Ming Lu, Zheng-Yan Zhu, Chun-Hua Wang, Department of Neurosurgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China
Ri-Sheng Liang, Department of Neurosurgery, Affiliated Union Hospital of Fujian Medical University, Neurosurgery Research Institute of Fujian Province, Fuzhou 350001, Fujian Province, China
Author contributions: Yang B and Wen HY contributed equally to this work; Yang B and Wen HY proposed the overall research goal and designed the research plan and model design; Yang B, Wen HY, Liang RS, and Lu TM conducted feasibility analysis, review, and supervision of the experiment; Yang B, Wen HY, Zhu ZY, and Wang CH conducted statistical processing and analysis of the data; Yang B and Wen HY are responsible for writing the first draft of the paper; Yang B, Wen HY, and Liang RS were responsible for the review, revision, and quality control of the paper; all authors determined the final draft of the paper.
Supported by Natural Science Foundation of Fujian Province of China, No. 2019J01317.
Institutional animal care and use committee statement: The Institutional Animal Care, Ethics, and Use Committees of Fujian Medical University (Fuzhou, China) approved all animal experiments, No. 2018-062.
Conflict-of-interest statement: The authors declare no competing interests.
Data sharing statement: The datasets generated and analyzed during the current study are available from the corresponding author upon reasonable request.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ri-Sheng Liang, PhD, Professor, Department of Neurosurgery, Affiliated Union Hospital of Fujian Medical University, Neurosurgery Research Institute of Fujian Province, No. 29 Xinquan Road, Fuzhou 350001, Fujian Province, China. email@example.com
Received: May 19, 2023
Peer-review started: May 19, 2023
First decision: June 1, 2023
Revised: July 4, 2023
Accepted: July 28, 2023
Article in press: July 28, 2023
Published online: September 19, 2023