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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Sep 19, 2022; 12(9): 1204-1232
Published online Sep 19, 2022. doi: 10.5498/wjp.v12.i9.1204
Published online Sep 19, 2022. doi: 10.5498/wjp.v12.i9.1204
Psychotic symptoms in bipolar disorder and their impact on the illness: A systematic review
Subho Chakrabarti, Navdeep Singh, Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, UT, India
Author contributions: Both the authors have contributed equally to the planning of this review, carrying out the literature search, analyzing and preparing the results, and writing the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Subho Chakrabarti, MD, Professor, Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, UT, India. subhochd@yahoo.com
Received: January 12, 2022
Peer-review started: January 12, 2022
First decision: April 18, 2022
Revised: May 2, 2022
Accepted: August 26, 2022
Article in press: August 26, 2022
Published online: September 19, 2022
Peer-review started: January 12, 2022
First decision: April 18, 2022
Revised: May 2, 2022
Accepted: August 26, 2022
Article in press: August 26, 2022
Published online: September 19, 2022
Core Tip
Core Tip: This systematic review examined the extent and impact of psychosis in 339 studies of bipolar disorder (BD). The results endorsed the high rates of all types of psychotic symptoms in BD. However, psychosis was associated with an adverse impact only in a few domains of the illness including the severity of BD, the rate/duration of hospitalizations, switches to BD, and poorer outcomes with mood-incongruent symptoms. No consistent associations were found in other areas, suggesting that psychosis is not always associated with a negative impact on BD. This finding conformed to the current consensus in the literature on psychotic BD.