Review
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatr. Dec 19, 2021; 11(12): 1177-1190
Published online Dec 19, 2021. doi: 10.5498/wjp.v11.i12.1177
Polyamines and polyamine-metabolizing enzymes in schizophrenia: Current knowledge and concepts of therapy
Hans-Gert Bernstein, Gerburg Keilhoff, Gregor Laube, Henrik Dobrowolny, Johann Steiner
Hans-Gert Bernstein, Henrik Dobrowolny, Johann Steiner, Department of Psychiatry, University of Magdeburg, Magdeburg D-39116, Saxony-Anhalt, Germany
Gerburg Keilhoff, Institute of Biochemistry and Cell Biology, University of Magdeburg, Magdeburg D-39116, Saxony-Anhalt, Germany
Gregor Laube, Department of Anatomy, Charite, Berlin D-10117, Germany
Author contributions: Bernstein HG designed the concept and wrote the paper; Keilhoff G contributed to the discussion and writing; Laube G contributed to the editing of the manuscript and review of the literature; Dobrowolny H designed Figure 1 and contributed to the discussion; Steiner J contributed to the writing and editing of the manuscript.
Conflict-of-interest statement: The authors report no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hans-Gert Bernstein, PhD, Emeritus Professor, Department of Psychiatry, University of Magdeburg, Leipziger Str. 44, Magdeburg D-39116, Saxony-Anhalt, Germany. hans-gert.bernstein@med.ovgu.de
Received: February 4, 2021
Peer-review started: February 4, 2021
First decision: April 21, 2021
Revised: April 30, 2021
Accepted: November 18, 2021
Article in press: November 18, 2021
Published online: December 19, 2021
Core Tip

Core Tip: This review summarizes the advancements in research on the implications of polyamines and their metabolites for schizophrenia. Evidence from clinical and experimental studies show that some members of the polyamine regulatory system are altered in schizophrenia, but no polyamine-based therapy for schizophrenia is currently available.