Published online Nov 19, 2021. doi: 10.5498/wjp.v11.i11.954
Peer-review started: February 25, 2021
First decision: May 13, 2021
Revised: June 5, 2021
Accepted: September 19, 2021
Article in press: September 19, 2021
Published online: November 19, 2021
Core Tip: Sleep hygiene is thought to be necessary for memory consolidation and learning while sleep disturbances can alter both synaptic plasticity and memory consolidation. Recent findings indicate that the expression of G-protein coupled receptors (GPCRs) like metabotropic glutamate receptors, gamma-amino butyric acid-B receptors and serotonin (5-hydroxytryptamine) receptors as well as synaptic plasticity are altered following a short episode of sleep deprivation. GPCRs are involved in a variety of central nervous system functions and are targets for therapeutic agents in psychiatry and other neurological disorders. Therefore, a deeper understanding of these receptors in association with the state of sleep and its related functions and disorders is needed.