Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatr. Nov 19, 2021; 11(11): 954-980
Published online Nov 19, 2021. doi: 10.5498/wjp.v11.i11.954
G-protein coupled receptors and synaptic plasticity in sleep deprivation
Shweta Parmar, Ramakrishna Tadavarty, Bhagavatula R Sastry
Shweta Parmar, Ramakrishna Tadavarty, Bhagavatula R Sastry, Department of Anesthesiology, Pharmacology and Therapeutics, The University of British Columbia, Vancouver V6T 1Z3, British Columbia, Canada
Author contributions: Parmar S, Tadavarty R and Sastry BR contributed equally to the outline of this review; Parmar S performed 85% of the writing work, and Tadavarty R performed 15%; Illustrations were done by Parmar S; Suggestions and corrections were contributed by Sastry BR; All authors have read and approved the manuscript.
Supported by Canadian Institutes of Health Research Grant, No. TGS-109219; and 4-Year Fellowship from the University of British Columbia.
Conflict-of-interest statement: Authors have nothing to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Bhagavatula R Sastry, PhD, Professor, Department of Anesthesiology, Pharmacology and Therapeutics, The University of British Columbia, 2176 Health Sciences Mall, Vancouver V6T 1Z3, British Columbia, Canada.
Received: February 25, 2021
Peer-review started: February 25, 2021
First decision: May 13, 2021
Revised: June 5, 2021
Accepted: September 19, 2021
Article in press: September 19, 2021
Published online: November 19, 2021
Core Tip

Core Tip: Sleep hygiene is thought to be necessary for memory consolidation and learning while sleep disturbances can alter both synaptic plasticity and memory consolidation. Recent findings indicate that the expression of G-protein coupled receptors (GPCRs) like metabotropic glutamate receptors, gamma-amino butyric acid-B receptors and serotonin (5-hydroxytryptamine) receptors as well as synaptic plasticity are altered following a short episode of sleep deprivation. GPCRs are involved in a variety of central nervous system functions and are targets for therapeutic agents in psychiatry and other neurological disorders. Therefore, a deeper understanding of these receptors in association with the state of sleep and its related functions and disorders is needed.