Qu JL, Lu HY, Fu XB, Gai WT. Correlation of resilience with anxiety and depression in patients with prostate cancer and analysis of influencing factors. World J Psychiatry 2025; 15(8): 102835 [DOI: 10.5498/wjp.v15.i8.102835]
Corresponding Author of This Article
Wen-Tao Gai, Department of Urology Surgery, Qingdao Hiser Hospital Affiliated of Qingdao University (Qingdao Traditional Chinese Medicine Hospital), No. 4 Renmin Road, Shibei District, Qingdao 266033, Shandong Province, China. gwtqdhc@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Psychiatry. Aug 19, 2025; 15(8): 102835 Published online Aug 19, 2025. doi: 10.5498/wjp.v15.i8.102835
Correlation of resilience with anxiety and depression in patients with prostate cancer and analysis of influencing factors
Jiang-Lei Qu, Hai-Yang Lu, Xiao-Bo Fu, Wen-Tao Gai
Jiang-Lei Qu, Hai-Yang Lu, Wen-Tao Gai, Department of Urology Surgery, Qingdao Hiser Hospital Affiliated of Qingdao University (Qingdao Traditional Chinese Medicine Hospital), Qingdao 266033, Shandong Province, China
Xiao-Bo Fu, Department of Oncology, Qingdao Hiser Hospital North Branch Affiliated of Qingdao University (Hongdao People’s Hospital of Qingdao), Qingdao 266033, Shandong Province, China
Co-first authors: Jiang-Lei Qu and Hai-Yang Lu.
Author contributions: Qu JL and Lu HY contributed equally to this work and are co-first authors; Qu JL, Lu HY, Fu XB, and Gai WT designed the research and wrote the first manuscript; Qu JL and Lu HY conceived the research, analyzed data, conducted the analysis, and provided guidance for the research; and all authors reviewed and approved the final manuscript.
Institutional review board statement: This study was approved by the Ethic Committee of Qingdao Hiser Hospital Affiliated of Qingdao University.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: All data and materials are available from the corresponding author.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wen-Tao Gai, Department of Urology Surgery, Qingdao Hiser Hospital Affiliated of Qingdao University (Qingdao Traditional Chinese Medicine Hospital), No. 4 Renmin Road, Shibei District, Qingdao 266033, Shandong Province, China. gwtqdhc@163.com
Received: February 7, 2025 Revised: March 19, 2025 Accepted: March 20, 2025 Published online: August 19, 2025 Processing time: 182 Days and 1.2 Hours
Abstract
BACKGROUND
The development of prostate cancer (PC) frequently intensifies negative emotional states, such as anxiety and depression, which compromise the effectiveness of radical surgery and reduce treatment adherence. In this study, we hypothesized that psychological resilience plays a crucial role in this process and explored its impact.
AIM
To investigate the association of resilience with anxiety and depression in patients with PC and to analyze the influencing factors.
METHODS
We selected 147 patients with PC who visited Qingdao Traditional Chinese Medicine Hospital from January 2022 to June 2024. The resilience scores of patients with PC were assessed using the Connor-Davidson Resilience Scale (CD-RISC) from the tenacity, self-improvement, and optimism dimensions. Based on the total CD-RISC score, patients were categorized into groups A (total CD-RISC score > 63 points, n = 69) and B (total CD-RISC score ≤ 63 points, n = 78) for comparative analysis of anxiety [Hamilton Anxiety Rating Scale (HAMA)], depression [Hamilton Depression Rating Scale (HAMD)], sexual function [International Index of Erectile Function-5 (IIEF-5) and Sexual Life Quality Questionnaire-Quality of Life (SLQQ-QOL)], and quality of life [the EORTC Core Quality of Life Questionnaire (QLQ-C30)]. The association between CD-RISC and the above indicators was analyzed with Spearman correlation coefficients, and the influencing factors of resilience in patients with PC were identified with binary logistic regression.
RESULTS
Group A demonstrated statistically lower HAMA and HAMD scores and markedly higher scores of IIEF-5, SLQQ-QOL, and various QLQ-C30 aspects. Correlation analysis revealed that CD-RISC was significantly negatively correlated with HAMA and HAMD scores and significantly positively correlated with IIEF-5, SLQQ-QOL, and QLQ-C30 total scores. Binary logistic regression analysis revealed educational and per capita monthly household income levels as significant influencing factors of resilience in patients with PC.
CONCLUSION
Our results indicate a significant correlation of resilience with anxiety and depression in patients with PC. The milder the anxiety and depression emotions in patients, the higher their resilience. Further, assisting patients with PC to improve their educational and per capita monthly household income levels will help their resilience to some extent.
Core Tip: Psychological resilience is an individual’s capacity to adapt to stressors and counteract the detrimental effects of future adverse events. In patients with prostate cancer, resilience acts as a protective buffer, facilitating effective emotional regulation and alleviating emotional distress. Despite its importance, research that examined the association between psychological resilience and anxiety or depression in patients with prostate cancer as well as the factors influencing this association remains limited. Our study reveals that higher psychological resilience levels are strongly associated with reduced anxiety and depression, improved sexual function, and enhanced overall quality of life. Furthermore, factors, such as higher educational attainment and greater monthly household income per capita positively contribute to the development of psychological resilience in these patients.
