Li X, Zhao W, Wei YH, Zhang XS, Zhu Y, Li XH. Perceived stress, risk factors and prognostic monitoring loci for the development of depression. World J Psychiatry 2025; 15(6): 105222 [DOI: 10.5498/wjp.v15.i6.105222]
Corresponding Author of This Article
Xu-Hao Li, MD, PhD, Assistant Professor, School of Acupuncture and Tuina, Shandong University of Traditional Chinese Medicine, No. 4655 University Road, Jinan 250355, Shandong Province, China. l1xuhao2022@163.com
Research Domain of This Article
Psychiatry
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Psychiatry. Jun 19, 2025; 15(6): 105222 Published online Jun 19, 2025. doi: 10.5498/wjp.v15.i6.105222
Perceived stress, risk factors and prognostic monitoring loci for the development of depression
Xuan Li, Wei Zhao, Yu-Han Wei, Xiao-Shuang Zhang, Yong Zhu, Xu-Hao Li
Xuan Li, Xiao-Shuang Zhang, Department of General Surgery, Linyi Hospital of Traditional Chinese Medicine, Linyi 276003, Shandong Province, China
Wei Zhao, Department of Otolaryngology, Linyi Hospital of Traditional Chinese Medicine, Linyi 276003, Shandong Province, China
Yu-Han Wei, School of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong Province, China
Yong Zhu, Department of Emergency Surgery, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong Province, China
Xu-Hao Li, School of Acupuncture and Tuina, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong Province, China
Co-first authors: Xuan Li and Wei Zhao.
Co-corresponding authors: Yong Zhu and Xu-Hao Li.
Author contributions: Li X and Zhang XS wrote the manuscript; Zhao W and Wei YH revised the manuscript; Zhu Y and Li XH designed the overall concept and outline of the manuscript; all authors contributed to this paper and have approved the final version of the manuscript.
Conflict-of-interest statement: There are no conflicts of interest in this study.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xu-Hao Li, MD, PhD, Assistant Professor, School of Acupuncture and Tuina, Shandong University of Traditional Chinese Medicine, No. 4655 University Road, Jinan 250355, Shandong Province, China. l1xuhao2022@163.com
Received: January 15, 2025 Revised: March 19, 2025 Accepted: March 20, 2025 Published online: June 19, 2025 Processing time: 134 Days and 21 Hours
Abstract
This article examines stress and its potential role in the development of depression. By reviewing existing literature, the article explores the possible role of stress in diagnosing and monitoring depression and highlights the importance of managing personal stress in the treatment of depression. The article also discusses the many ways that stress and depression are connected, and suggests ideas for subsequent investigations. This includes developing more exact ways to measure biomarkers, exploring treatments that are not based on drugs, and looking at the effect that society has on depression.
Core Tip: In this editorial, we provide an overview of the relationship between stress and depression. The potential role of stress in the diagnosis and prognostic monitoring of depression is analysed through the existing literature with the aim of providing new perspectives on the prevention, diagnosis and treatment of depression. This article will further emphasise the importance of uncovering stress biomarkers in depression.
