Published online Feb 6, 2017. doi: 10.5315/wjh.v6.i1.11
Peer-review started: September 1, 2016
First decision: October 26, 2016
Revised: November 18, 2016
Accepted: December 16, 2016
Article in press: December 19, 2016
Published online: February 6, 2017
Core tip: Disseminated intravascular coagulation (DIC) is a syndrome characterized by the systemic activation of blood clotting, which generates large amount of intravascular thrombin and fibrin. In the context of severe sepsis and septic shock, DIC is related to increased severity, greater number and seriousness of organ failures, more frequent side-effects from treatment itself, and worse outcomes. We ought to review the most important and updated information available in the literature about DIC in severe sepsis and septic shock.