Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hematol. Feb 6, 2017; 6(1): 11-16
Published online Feb 6, 2017. doi: 10.5315/wjh.v6.i1.11
Current approach to disseminated intravascular coagulation related to sepsis - organ failure type
Jose J Zaragoza, Missael V Espinoza-Villafuerte
Jose J Zaragoza, Missael V Espinoza-Villafuerte, Intensive Care Unit, Hospital Español, Mexico City 11520, Mexico
Author contributions: Zaragoza JJ and Espinoza-Villafuerte MV contributed equally to the work, participating in collection of the data and writing the manuscript and approving the final version of it.
Conflict-of-interest statement: The authors declare no conflicts of interest regarding this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Jose J Zaragoza, MD, Intensive Care Unit, Hospital Español, Ejercito Nacional 613 Piso 9, Granada, Mexico City 11520, Mexico.
Telephone: +52-55-52559600
Received: August 29, 2016
Peer-review started: September 1, 2016
First decision: October 26, 2016
Revised: November 18, 2016
Accepted: December 16, 2016
Article in press: December 19, 2016
Published online: February 6, 2017
Core Tip

Core tip: Disseminated intravascular coagulation (DIC) is a syndrome characterized by the systemic activation of blood clotting, which generates large amount of intravascular thrombin and fibrin. In the context of severe sepsis and septic shock, DIC is related to increased severity, greater number and seriousness of organ failures, more frequent side-effects from treatment itself, and worse outcomes. We ought to review the most important and updated information available in the literature about DIC in severe sepsis and septic shock.