Published online Feb 2, 2015. doi: 10.5314/wjd.v4.i1.1
Peer-review started: May 28, 2014
First decision: July 30, 2014
Revised: October 10, 2014
Accepted: December 29, 2014
Article in press: December 31, 2014
Published online: February 2, 2015
Core tip: The review concerns the literature on modifi-cations of sphingolipids in the stratum corneum (SC) of atopic dogs. We gave for the first time a detailed biochemical analysis of dog lipids in the successive layers of the SC take by tape stripping, and discussed their specificity by comparison to humans. We showed also the specific composition in protein-bound ceramides and the importance of CerOS in dog skin for barrier integrity. The lipid composition of involved and non-involved skin areas in atopic dogs was described and we showed how a topical or oral treatment can restore the lipid composition of SC and reconstruct the barrier integrity.