Published online Feb 2, 2015. doi: 10.5314/wjd.v4.i1.1
Peer-review started: May 28, 2014
First decision: July 30, 2014
Revised: October 10, 2014
Accepted: December 29, 2014
Article in press: December 31, 2014
Published online: February 2, 2015
The present paper is in the same time an overview of the literature concerning the alterations of lipids in the stratum corneum (SC) of atopic dogs and a review of data based on our publications. Knowing the importance of the SC barrier function for against pathogens in atopic dermatitis, we show for the first time a detailed biochemical analysis of lipids corresponding to the same amount of proteins in the successive layers of canine SC taken using tape stripping and their specificity as compared to humans. Also we show new results concerning the changes in the composition for protein-bound ceramides, and for the other lipids in involved and non-involved skin areas in atopic dogs. We show how a topical or oral treatment can restore the SC lipid composition and reconstruct the barrier integrity by up-regulating the biosynthesis of protein-bound ceramides.
Core tip: The review concerns the literature on modifi-cations of sphingolipids in the stratum corneum (SC) of atopic dogs. We gave for the first time a detailed biochemical analysis of dog lipids in the successive layers of the SC take by tape stripping, and discussed their specificity by comparison to humans. We showed also the specific composition in protein-bound ceramides and the importance of CerOS in dog skin for barrier integrity. The lipid composition of involved and non-involved skin areas in atopic dogs was described and we showed how a topical or oral treatment can restore the lipid composition of SC and reconstruct the barrier integrity.