Case Control Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Feb 18, 2017; 8(2): 149-155
Published online Feb 18, 2017. doi: 10.5312/wjo.v8.i2.149
Interleukin-6 and ratio of plasma interleukin-6/interleukin-10 as risk factors of symptomatic lumbar osteoarthritis
I Ketut Suyasa, I Ketut Siki Kawiyana, I Made Bakta, I Gde Raka Widiana
I Ketut Suyasa, I Ketut Siki Kawiyana, Department of Orthopaedic and Traumatology, Faculty of Medicine, Udayana University Sanglah General Hospital, Bali 80113, Indonesia
I Made Bakta, I Gde Raka Widiana, Department of Internal Medicine, Faculty of Medicine, Udayana University Sanglah General Hospital, Bali 80113, Indonesia
Author contributions: Suyasa IK designed the research and collect material and clinical data from patients; Kawiyana IKS collect material and clinical data from patients; Bakta IM wrote the paper; Widiana IGR analyzed the data.
Institutional review board statement: The study was approved by the ethics committee of Sanglah General Hospital (Bali, Indonesia).
Informed consent statement: All patients gave informed consent.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest regarding this work.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. I Ketut Suyasa, SpB, SpOT(K) Spine, Department of Orthopaedic and Traumatology, Faculty of Medicine, Udayana University Sanglah General Hospital, Denpasar, Bali 80113, Indonesia. iksysa@gmail.com
Telephone: +62-361-227911 Fax: +62-361-224206
Received: September 17, 2016
Peer-review started: September 19, 2016
First decision: October 21, 2016
Revised: November 18, 2016
Accepted: December 7, 2016
Article in press: December 9, 2016
Published online: February 18, 2017
Core Tip

Core tip: High levels of cartilage oligomeric matrix protein in estrogen deficiency postmenopausal women were not at risk for symptomatic lumbar osteoarthritis (OA). Estrogen-deficient postmenopausal women with the high levels of interleukin (IL)-6 had higher risk for symptomatic lumbar OA from the low level of IL-6. At lower levels of IL-10, there was no risk for symptomatic lumbar OA than with the higher levels of IL-10. High ratio of IL-6/IL-10 levels in estrogen deficiency postmenopausal women produced higher risk for symptomatic lumbar OA.