Case Control Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Feb 18, 2017; 8(2): 149-155
Published online Feb 18, 2017. doi: 10.5312/wjo.v8.i2.149
Interleukin-6 and ratio of plasma interleukin-6/interleukin-10 as risk factors of symptomatic lumbar osteoarthritis
I Ketut Suyasa, I Ketut Siki Kawiyana, I Made Bakta, I Gde Raka Widiana
I Ketut Suyasa, I Ketut Siki Kawiyana, Department of Orthopaedic and Traumatology, Faculty of Medicine, Udayana University Sanglah General Hospital, Bali 80113, Indonesia
I Made Bakta, I Gde Raka Widiana, Department of Internal Medicine, Faculty of Medicine, Udayana University Sanglah General Hospital, Bali 80113, Indonesia
Author contributions: Suyasa IK designed the research and collect material and clinical data from patients; Kawiyana IKS collect material and clinical data from patients; Bakta IM wrote the paper; Widiana IGR analyzed the data.
Institutional review board statement: The study was approved by the ethics committee of Sanglah General Hospital (Bali, Indonesia).
Informed consent statement: All patients gave informed consent.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest regarding this work.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. I Ketut Suyasa, SpB, SpOT(K) Spine, Department of Orthopaedic and Traumatology, Faculty of Medicine, Udayana University Sanglah General Hospital, Denpasar, Bali 80113, Indonesia. iksysa@gmail.com
Telephone: +62-361-227911 Fax: +62-361-224206
Received: September 17, 2016
Peer-review started: September 19, 2016
First decision: October 21, 2016
Revised: November 18, 2016
Accepted: December 7, 2016
Article in press: December 9, 2016
Published online: February 18, 2017
Abstract
AIM

To determine the role of cartilage oligomeric matrix protein (COMP), interleukin (IL)-6, IL-10 and ratio of IL-6/IL-10 as risk factors of symptomatic lumbar osteoarthritis (OA) in postmenopausal women with estrogen deficiency.

METHODS

Case-control study had been conducted in Sanglah General Hospital from October 2015 until March 2016. The blood samples were obtained and analyzed by enzyme-linked immunosorbent assay (ELISA).

RESULTS

From 44 pairs of samples which divided into 44 samples as case group and 44 samples as control group showed that high level of COMP in estrogen deficiency postmenopausal women were not at risk (OR = 0.7; 95%CI: 0.261-1.751; P = 0.393) for symptomatic lumbar OA (cut-off point 0.946). Estrogen deficiency in postmenopausal women with the high level of IL-6 had 2.7 times risk (OR = 2.7; 95%CI: 0.991-8.320; P = 0.033) for symptomatic lumbar OA from the low level of IL-6 (cut-off point 2.264). At lower level of IL-10, there was no risk for symptomatic lumbar OA (OR = 0.6; 95%CI: 0.209-1.798; P = 0.345) than with the higher level of IL-10 (cut-off point 6.049). While the high ratio of IL-6/IL-10 level in estrogen deficiency postmenopausal women gave 3.4 times risk (OR = 3.4; 95%CI: 1.204-11.787; P = 0.011) for symptomatic lumbar OA than the low ratio of IL-6/IL-10 level (cut-off point 0.364).

CONCLUSION

High ratio of IL-6/IL-10 plasma level was the highest risk factor for causing symptomatic lumbar OA in postmenopausal women with estrogen deficiency.

Keywords: Symptomatic lumbar osteoarthritis, Ratio of interleukin-6/interleukin-10, Interleukin-6, Interleukin-10, Cartilage oligomeric matrix protein

Core tip: High levels of cartilage oligomeric matrix protein in estrogen deficiency postmenopausal women were not at risk for symptomatic lumbar osteoarthritis (OA). Estrogen-deficient postmenopausal women with the high levels of interleukin (IL)-6 had higher risk for symptomatic lumbar OA from the low level of IL-6. At lower levels of IL-10, there was no risk for symptomatic lumbar OA than with the higher levels of IL-10. High ratio of IL-6/IL-10 levels in estrogen deficiency postmenopausal women produced higher risk for symptomatic lumbar OA.