Published online Dec 18, 2015. doi: 10.5312/wjo.v6.i11.1006
Peer-review started: May 25, 2015
First decision: August 4, 2015
Revised: September 23, 2015
Accepted: October 23, 2015
Article in press: October 27, 2015
Published online: December 18, 2015
Core tip: In this systematic review regarding Cartilage Autograft Implantation System (CAIS) and Particulated Juvenile Allograft Cartilage (PJAC), basic science and clinical articles with more than 10 patients treated and more than 6 mo of follow-up were included. A total of 17 articles were available for the present review. Good basic science evidence in vitro and in vivo was described to support the concept of CAIS. Only one level II paper reported the clinical results of the CAIS technique. On the other hand, little basic science evidence and 4 preliminary clinical trials are available regarding the PJAC technique. CAIS and PJAC represent promising single step solutions for cartilage restoration with hyaline-like repair. However, many controversies still exist regarding both techniques, including the indications (age of the patients, size of the lesion, and involvement of the subchondral bone).